928045-65-2Relevant academic research and scientific papers
Rapid and slow generation of 1-trifluoromethylvinyllithium: syntheses and applications of CF3-containing allylic alcohols, allylic amines, and vinyl ketones
Nadano, Ryo,Fuchibe, Kohei,Ikeda, Masahiro,Takahashi, Hiroki,Ichikawa, Junji
supporting information; experimental part, p. 1875 - 1883 (2011/04/22)
1-(Trifluoromethyl)vinylation is accomplished in two protocols by the in situ generation of thermally unstable 3,3,3-trifluoroprop-1-en-2-yllithium (1):1) a rapid lithium-halogen-exchange reaction of 2-bromo-3,3,3-trifluoroprop- 1-ene (2) takes effect wit
A facile synthesis of N-[2-(trifluoromethyl)allyl]amides and their transformation into angularly trifluoromethylated bicyclic cyclopentenones
Nadano, Ryo,Ichikawa, Junji
, p. 22 - 23 (2007/10/03)
On treatment with sec-BuLi at -105°C, 2-bromo-3,3,3-trifluoropropene undergoes rapid lithium-halogen exchange to generate thermally unstable 1-(trifluoromethyl)vinyllithium, which reacts with W-tosylimines to afford N-[2-(trifluoromethyl)allyl] amides in high yield. Propargylation of the amides, followed by the Pauson-Khand reaction, readily provides pyrrolidine ring-fused cyclopentenones with an angular trifluoromethyl group. Copyright
