928050-51-5

Upstream product

• 928050-50-4 C₁₂H₁₄Br₂O 
• 925-90-6 ethylmagnesium bromide 
• 70144-17-1 (S)-3-hydroxypent-1-yne 
• 98-88-4 benzoyl chloride 
• 928050-49-1 (2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane 
• 80928-04-7 (S)-(-)-2-Benzyloxybutyraldehyde 

Downstream Products

• 928050-52-6 C₂₁H₂₈O₄ 
• 928050-53-7 C₂₈H₃₄O₅ 

Relevant academic research and scientific papers

Asymmetric hydrogenation of alkynyl ketones with the η6- arene/TsDPEN-ruthenium(II) catalyst

Enantioselective hydrogenation of alkynyl ketones catalyzed by Ru(OTf)(TsDPEN)(η6-p-cymene) (TsDPEN = N-(p-toluenesulfonyl)-1,2- diphenylethylenediamine) affords the propargylic alcohols in up to 97% ee. The alkynyl moieties are left intact in most cases. The reaction can be conducted with a substrate-to-catalyst molar ratio as high as 5000 under 10 atm of H 2. The mode of enantioselection is elucidated with the transition state models directed by the CH/π attractive interaction between the substrate and the catalytic species.

Stereoselective synthesis of (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundecanoic acid δ-lactone

A stereoselective synthesis of the pentaketide lactone (3R,4S,5S,9S)-3,5,9-trihydroxy-4-methylundecanoic acid δ-lactone has been achieved.