928118-87-0

Basic information

• Product Name: 5-Pyrimidinecarboxylic acid, 4-methyl-6-phenyl-2-[(phenylmethyl)amino]-, ethyl ester
• CAS NO: 928118-87-0
• Molecular Formula: C21H21N3O2
• Molecular Weight: 347.417
• Mol File: 928118-87-0.mol

Chemical Properties

• CAS DataBase Reference: 5-Pyrimidinecarboxylic acid, 4-methyl-6-phenyl-2-[(phenylmethyl)amino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Pyrimidinecarboxylic acid, 4-methyl-6-phenyl-2-[(phenylmethyl)amino]-, ethyl ester(928118-87-0)
• EPA Substance Registry System: 5-Pyrimidinecarboxylic acid, 4-methyl-6-phenyl-2-[(phenylmethyl)amino]-, ethyl ester(928118-87-0)

Safety Data

• Hazardous Substances Data: 928118-87-0(Hazardous Substances Data)

Upstream product

• 36746-07-3 2-chloro-4-methyl-6-phenylpyrimidine-5-carboxylic acid ethyl ester 
• 100-46-9 benzylamine 
• 123237-03-6 ethyl 6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one-5-carboxylate 
• 69207-36-9 ethyl 6-methyl-4-phenylpyrimidin-2(1H)-one-5-carboxylate 
• 69207-36-9 ethyl 2-hydroxy-4-methyl-6-phenylpyrimidine-5-carboxylate 

Relevant articles and documents

Copper(i) chloride promoted Csp2-N cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with amines: An efficient approach to obtain C2-amino functionalized pyrimidines

The copper(i)-promoted cross-coupling of 1,2-di(pyrimidin-2-yl) disulfides with aromatic amines and aliphatic amines to deliver C-N coupling products in moderate to good yields is reported in this paper. Central to this strategy is the conversion of disulfides into aryl- and alkyl amines by a copper-promoted chemoselective C-S bond cleavage.

Nucleophilic Substitution Reaction of Pyrimidin-2-yl Phosphates Using Amines and Thiols as Nucleophiles Mediated by PEG-400 as an Environmentally Friendly Solvent

A metal-free synthesis of C2-functionalized pyrimidines via the reaction of pyrimidin-2-yl phosphates with amines and thiophenols in PEG-400 has been developed. The desired products can be generated in good to excellent yields in the environmentally friendly PEG-400, without any catalysts or other additives.

Facile transformation of Biginelli pyrimidin-2(1H)-ones to pyrimidines. In vitro evaluation as inhibitors of Mycobacterium tuberculosis and modulators of cytostatic activity

A series of pyrimidine derivatives bearing amine substituents at C-2 position were obtained from Biginelli 3,4-dihydropyrimidin-2(1H)-ones and the effect of structural variation on anti-TB activity against Mycobacterium tuberculosis H37Rv strai