92823-03-5

Basic information

• Product Name: Flomoxef sodium
• Synonyms: 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, monosodium salt, (6R,7R)-;5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, monosodium salt, (6R-cis)-;6315 S Shionogi;6315S;Flomoxef sodium salt;(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;Flomoxef sodium;(6R,6β)-7α-[[[(Difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7β-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
• CAS NO: 92823-03-5
• Molecular Formula: C₁₅H₁₇F₂N₆O₇S₂*Na
• Molecular Weight: 518.45
• EINECS: 1308068-626-2
• Mol File: 92823-03-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.85g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Flomoxef sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Flomoxef sodium(92823-03-5)
• EPA Substance Registry System: Flomoxef sodium(92823-03-5)

Safety Data

• Hazardous Substances Data: 92823-03-5(Hazardous Substances Data)

Usage

Uses

Flomoxef Sodium is a sodium salt derivative of Flomoxef (F401850); an oxacephem derived beta-lactam antibiotic that is particularly effective against gram-positive bacteria.

InChI:InChI=1/C15H18F2N6O7S2.Na/c1-29-15(18-8(25)6-31-13(16)17)11(28)23-9(10(26)27)7(4-30-12(15)23)5-32-14-19-20-21-22(14)2-3-24;/h12-13,24H,2-6H2,1H3,(H,18,25)(H,26,27);/q;+1/p-1/t12-,15+;/m1./s1

Upstream product

• 99665-00-6 flomoxef 
• 68314-38-5 (6R,7R)-benzhydryl 7-(4-methylbenzamide)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 949587-46-6 (6R,7R)-7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-formic acid diphenylmethyl ester 
• 103057-61-0 (6R,7R)-7-(amino)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-formic acid diphenylmethyl ester 

Relevant articles and documents

Crystal form of flomoxef sodium, preparation method, pharmaceutical composition and application

The invention provides a crystal form of flomoxef sodium. An X-ray diffraction pattern of the crystal form comprises X-ray diffraction peaks as shown in the following 2[theta] angles: 5.2 +/-0.2 degrees and 16.2 +/-0.2 degrees. In addition, the invention also discloses a preparation method of the crystal form compound, a pharmaceutical composition and application of the crystal form compound and the pharmaceutical composition in preparation of anti-bacterial infection drugs. Compared with an amorphous product prepared by a freeze-drying process, the novel crystal form obtained by the preparation method disclosed by the invention has the advantages that the stability of the novel crystal form is obviously superior to that of the amorphous form, which means that the crystal form disclosed bythe invention has less degradation impurity generation and lower drug storage condition requirements within the validity period, and has a good medicinal use prospect.

Method for producing Flomoxef Sodium

Disclosed is a method of producing flomoxef sodium which is an oxacephem-based antibiotic and has a wide antibacterial activity against various flora. The method of producing flomoxef sodium comprises the steps of: making flomoxef acid react with a sodium ion source in an organic solvent; and crystallizing the flomoxef sodium, which is a reaction product, by filtering and drying a reactant of the previous reaction. Here, it is preferred that a solvent with a low solubility of the flomoxef sodium among the acetone, methyl ethyl ketone, isobutyl ketone, methyl acetate, ethyl acetate, diethyl ether, isopropyl ether, t-butyl methyl ether, tetrahydrofuran, dichloromethane, chloroform, acetonitrile, ethanol, isopropyl alcohol, and a mixture thereof is used as the organic solvent. According to the present invention, high purity flomoxef sodium can be obtained at a high yield.