92823-03-5

Basic information

• Product Name: Flomoxef sodium
• Synonyms: 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, monosodium salt, (6R,7R)-;5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[[(difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7-methoxy-8-oxo-, monosodium salt, (6R-cis)-;6315 S Shionogi;6315S;Flomoxef sodium salt;(6R,7R)-7-(2-((Difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt;Flomoxef sodium;(6R,6β)-7α-[[[(Difluoromethyl)thio]acetyl]amino]-3-[[[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]thio]methyl]-7β-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
• CAS NO: 92823-03-5
• Molecular Formula: C₁₅H₁₇F₂N₆O₇S₂*Na
• Molecular Weight: 518.45
• EINECS: 1308068-626-2
• Mol File: 92823-03-5.mol

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.85g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: Flomoxef sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Flomoxef sodium(92823-03-5)
• EPA Substance Registry System: Flomoxef sodium(92823-03-5)

Safety Data

• Hazardous Substances Data: 92823-03-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Flomoxef sodium is used as an antibiotic for the treatment of bacterial infections caused by gram-positive bacteria. Its effectiveness against these bacteria makes it a valuable tool in combating infections and promoting recovery in patients.
Used in Medical Treatments:
Flomoxef sodium is used as a therapeutic agent for treating a variety of infections, including respiratory tract infections, skin and soft tissue infections, and urinary tract infections. Its broad-spectrum activity against gram-positive bacteria contributes to its utility in managing these conditions.
Used in Research and Development:
Flomoxef sodium is utilized in research and development for studying the mechanisms of action of beta-lactam antibiotics and their interactions with bacterial cells. This knowledge can contribute to the development of new antibiotics and strategies for combating antibiotic resistance.

InChI:InChI=1/C15H18F2N6O7S2.Na/c1-29-15(18-8(25)6-31-13(16)17)11(28)23-9(10(26)27)7(4-30-12(15)23)5-32-14-19-20-21-22(14)2-3-24;/h12-13,24H,2-6H2,1H3,(H,18,25)(H,26,27);/q;+1/p-1/t12-,15+;/m1./s1

Upstream product

• 99665-00-6 flomoxef 
• 103057-61-0 (6R,7R)-7-(amino)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-formic acid diphenylmethyl ester 
• 949587-46-6 (6R,7R)-7-(2-((difluoromethyl)thio)acetamido)-3-(((1-(2-hydroxyethyl)-1H-tetrazol-5-yl)thio)methyl)-7-methoxyl-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-formic acid diphenylmethyl ester 
• 68314-38-5 (6R,7R)-benzhydryl 7-(4-methylbenzamide)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 

Relevant articles and documents

Crystal form of flomoxef sodium, preparation method, pharmaceutical composition and application

The invention provides a crystal form of flomoxef sodium. An X-ray diffraction pattern of the crystal form comprises X-ray diffraction peaks as shown in the following 2[theta] angles: 5.2 +/-0.2 degrees and 16.2 +/-0.2 degrees. In addition, the invention also discloses a preparation method of the crystal form compound, a pharmaceutical composition and application of the crystal form compound and the pharmaceutical composition in preparation of anti-bacterial infection drugs. Compared with an amorphous product prepared by a freeze-drying process, the novel crystal form obtained by the preparation method disclosed by the invention has the advantages that the stability of the novel crystal form is obviously superior to that of the amorphous form, which means that the crystal form disclosed bythe invention has less degradation impurity generation and lower drug storage condition requirements within the validity period, and has a good medicinal use prospect.

A method for the preparation of fluorine oxygen spore sodium

The invention belongs to a new flomoxef sodium preparation method, and particularly relates to a preparation method of flomoxef sodium. The method comprises the steps of: enabling a compound (I) to react with methyl alcohol to generate a compound (II) under the catalysis of ceric ammonium nitrate, next connecting with a tetrazole side chain to obtain a compound (III), removing an amino protection group and a hydroxyl protection group under enzymolysis to obtain a compound (IV), reacting with an intermediate of difluromethylation mercaptoacetic acid active ester to obtain a compound (V), removing the hydroxyl protection group under the effect of trifluoroacetic acid to obtain a compound (VI), and finally obtaining the flomoxef sodium (VII) through a formed sodium salt reaction. The reaction route is as follows. The method provided by the invention has the following advantages that the reaction operation is simple, convenient and reliable, the reaction route is short, the aims of going green and environmental protection, and high productivity are realized, the after-treatment is easy and high-purity flomoxef sodium is obtained.

Method for producing Flomoxef Sodium

Disclosed is a method of producing flomoxef sodium which is an oxacephem-based antibiotic and has a wide antibacterial activity against various flora. The method of producing flomoxef sodium comprises the steps of: making flomoxef acid react with a sodium ion source in an organic solvent; and crystallizing the flomoxef sodium, which is a reaction product, by filtering and drying a reactant of the previous reaction. Here, it is preferred that a solvent with a low solubility of the flomoxef sodium among the acetone, methyl ethyl ketone, isobutyl ketone, methyl acetate, ethyl acetate, diethyl ether, isopropyl ether, t-butyl methyl ether, tetrahydrofuran, dichloromethane, chloroform, acetonitrile, ethanol, isopropyl alcohol, and a mixture thereof is used as the organic solvent. According to the present invention, high purity flomoxef sodium can be obtained at a high yield.

PROCESS FOR PREPARING FLOMOXEF SODIUM

The present invention refers to oxa cephem (oxacephem) in antibiotics sodium [...] flow which is used in the crystallization method relates to desired colors and being obtained by method (flomoxef sodium), flow [...] acid dissolving the a solvent, the organic or inorganic sodium salt reacting a metal salt of the solution, and cooling the reaction mixture sodium [...] flow includes for crystallizing. According to of the present invention method, flow [...] sodium the time and expensive freeze drying is not since the producing crystallization method, freeze-dried first step molding machine and not general forwardly predominantly in production facilities easy to is sodium [...] flow in method may be obtained in a high yield.