68314-38-5

Usage

Uses

Used in Pharmaceutical Industry:
(6R,7R)-3-Chloromethyl-7-methoxy-8-oxo-7-(p-toluoylamino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester is used as a potential drug candidate for its unique structural features and functional groups that may contribute to biological activities and medicinal properties. Its complex nature positions it as a promising compound for the development of new therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (6R,7R)-3-Chloromethyl-7-methoxy-8-oxo-7-(p-toluoylamino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester serves as a key intermediate in the synthesis of pharmaceutical compounds. Its structural complexity and the presence of various functional groups make it an interesting subject for further study and exploration, potentially leading to the discovery of novel drugs and therapeutic agents.

Upstream product

• 67-56-1 methanol 
• 865-34-9 lithium methanolate 
• 91177-27-4 7-(N-4-methylbenzamide)-3-(chloromethyl)-8-oxo-5-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester 
• 68313-81-5 diphenylmethyl (2R,6R,7R)-3-methylene-7-[(4-methylbenzoyl)amino]-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylate 
• 67978-05-6 C₂₉H₂₆N₂O₄ 
• 82468-41-5 C₂₉H₂₈N₂O₅S 
• 17028-66-9 6β-(4-toluamido)penicillanic acid 
• 67977-95-1 diphenylmethyl 6β-(4-toluamido)penicillate 1-oxide 
• 104101-66-8 diphenylmethyl 6β-(4-toluamido)penicillanate 
• 91-01-0 1,1-Diphenylmethanol 

Downstream Products

• 134237-56-2 (6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate 
• 1370637-72-1 C₃₀H₂₆Cl₂N₂O₆S 
• 1370637-57-2 C₃₀H₂₈F₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-79-8 C₃₃H₃₂F₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-82-3 C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-86-7 C₃₅H₃₁ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-89-0 C₃₈H₃₅ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-91-4 C₃₆H₃₁ClN₅O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-94-7 C₃₅H₃₀Cl₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-97-0 C₃₈H₃₄Cl₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-00-8 C₃₆H₃₀Cl₂N₅O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-07-5 C₂₂H₂₁ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-10-0 C₂₅H₂₅ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-12-2 C₂₃H₂₁ClN₅O₆S⁽¹⁺⁾*I^(1-) 

Relevant academic research and scientific papers

A method for the preparation of fluorine oxygen spore sodium

The invention belongs to a new flomoxef sodium preparation method, and particularly relates to a preparation method of flomoxef sodium. The method comprises the steps of: enabling a compound (I) to react with methyl alcohol to generate a compound (II) under the catalysis of ceric ammonium nitrate, next connecting with a tetrazole side chain to obtain a compound (III), removing an amino protection group and a hydroxyl protection group under enzymolysis to obtain a compound (IV), reacting with an intermediate of difluromethylation mercaptoacetic acid active ester to obtain a compound (V), removing the hydroxyl protection group under the effect of trifluoroacetic acid to obtain a compound (VI), and finally obtaining the flomoxef sodium (VII) through a formed sodium salt reaction. The reaction route is as follows. The method provided by the invention has the following advantages that the reaction operation is simple, convenient and reliable, the reaction route is short, the aims of going green and environmental protection, and high productivity are realized, the after-treatment is easy and high-purity flomoxef sodium is obtained.

A method for preparing 1-Oxacephalosporin derivatives

The present invention relates to a novel method for preparing 1-oxacephalosporin derivatives as an intermediate for synthesizing 1-oxacephalosporin which is useful for an antimicrobial. The preparation method of the present invention uses a simple halogenation agent. Accordingly, stability is excellent, and a reaction process is simple, and it is easy to control reaction. Also, reaction time is short so that the method is very efficient. The present invention can improve manufacturing yield of 1-oxacephalosporin which is useful for the antimicrobial.

Design, synthesis and antibacterial activity of novel 1-oxacephem analogs

A series of 1-oxacephem analogs were synthesized and their antibacterial properties against five strains of Gram-positive and Gram-negative bacteria were evaluated in vitro while ceftazidine was selected as control. Some of the tested compounds, compound 12c in particular, showed more active against three selected strains than the standard.