68314-38-5

Basic information

• Product Name: (6R,7R)-3-Chloromethyl-7-methoxy-8-oxo-7-(p-toluoylamino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester
• Synonyms: (6R,7R)-3-Chloromethyl-7-methoxy-8-oxo-7-(p-toluoylamino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester;(6R,7R)-3-ChloroMethyl-7-Methoxy-8-oxo-7-(p-toluoylaMino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylMethyl este;(6R,7R)-benzhydryl 7-(4-methylbenzamide)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate
• CAS NO: 68314-38-5
• Molecular Formula: C₃₀H₂₇ClN₂O₆
• Molecular Weight: 547
• Mol File: 68314-38-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 744.2±60.0 °C(Predicted)
• Appearance: /
• Density: 1.38±0.1 g/cm3(Predicted)
• PKA: 11.61±0.60(Predicted)
• CAS DataBase Reference: (6R,7R)-3-Chloromethyl-7-methoxy-8-oxo-7-(p-toluoylamino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6R,7R)-3-Chloromethyl-7-methoxy-8-oxo-7-(p-toluoylamino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(68314-38-5)
• EPA Substance Registry System: (6R,7R)-3-Chloromethyl-7-methoxy-8-oxo-7-(p-toluoylamino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester(68314-38-5)

Safety Data

• Hazardous Substances Data: 68314-38-5(Hazardous Substances Data)

Usage

General Description

The chemical compound "(6R,7R)-3-Chloromethyl-7-methoxy-8-oxo-7-(p-toluoylamino)-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester" is a complex molecule with several functional groups. It contains a chlorine atom, a methoxy group, a ketone group, and an ester group. The compound is a derivative of a bicyclic ring structure and has a toluoylamino substituent. It appears to be a potential drug candidate or a key intermediate in the synthesis of pharmaceutical compounds due to its structural complexity. Its unique structure and functional groups may contribute to its potential biological activities and medicinal properties, making it of interest for further study and exploration in the field of medicinal chemistry.

Upstream product

• 67-56-1 methanol 
• 865-34-9 lithium methanolate 
• 91177-27-4 7-(N-4-methylbenzamide)-3-(chloromethyl)-8-oxo-5-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester 
• 104101-66-8 diphenylmethyl 6β-(4-toluamido)penicillanate 
• 91-01-0 1,1-Diphenylmethanol 
• 68313-81-5 diphenylmethyl (2R,6R,7R)-3-methylene-7-[(4-methylbenzoyl)amino]-8-oxo-5-oxa-1-azabicyclo[4.2.0]octane-2-carboxylate 
• 67978-05-6 C₂₉H₂₆N₂O₄ 
• 82468-41-5 C₂₉H₂₈N₂O₅S 
• 17028-66-9 6β-(4-toluamido)penicillanic acid 
• 67977-95-1 diphenylmethyl 6β-(4-toluamido)penicillate 1-oxide 

Downstream Products

• 134237-56-2 (6R,7R)-benzhydryl (7-(2-difluoromethylthio)acetamido)-3-(chloromethyl)-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4,2,0]oct-2-ene-2-carboxylate 
• 1370637-72-1 C₃₀H₂₆Cl₂N₂O₆S 
• 1370637-57-2 C₃₀H₂₈F₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-79-8 C₃₃H₃₂F₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-82-3 C₃₁H₂₈F₂N₅O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-86-7 C₃₅H₃₁ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-89-0 C₃₈H₃₅ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-91-4 C₃₆H₃₁ClN₅O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-94-7 C₃₅H₃₀Cl₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370637-97-0 C₃₈H₃₄Cl₂N₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-00-8 C₃₆H₃₀Cl₂N₅O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-07-5 C₂₂H₂₁ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-10-0 C₂₅H₂₅ClN₃O₆S⁽¹⁺⁾*I^(1-) 
• 1370638-12-2 C₂₃H₂₁ClN₅O₆S⁽¹⁺⁾*I^(1-) 

Relevant articles and documents

A method for the preparation of fluorine oxygen spore sodium

The invention belongs to a new flomoxef sodium preparation method, and particularly relates to a preparation method of flomoxef sodium. The method comprises the steps of: enabling a compound (I) to react with methyl alcohol to generate a compound (II) under the catalysis of ceric ammonium nitrate, next connecting with a tetrazole side chain to obtain a compound (III), removing an amino protection group and a hydroxyl protection group under enzymolysis to obtain a compound (IV), reacting with an intermediate of difluromethylation mercaptoacetic acid active ester to obtain a compound (V), removing the hydroxyl protection group under the effect of trifluoroacetic acid to obtain a compound (VI), and finally obtaining the flomoxef sodium (VII) through a formed sodium salt reaction. The reaction route is as follows. The method provided by the invention has the following advantages that the reaction operation is simple, convenient and reliable, the reaction route is short, the aims of going green and environmental protection, and high productivity are realized, the after-treatment is easy and high-purity flomoxef sodium is obtained.

Design, synthesis and antibacterial activity of novel 1-oxacephem analogs

A series of 1-oxacephem analogs were synthesized and their antibacterial properties against five strains of Gram-positive and Gram-negative bacteria were evaluated in vitro while ceftazidine was selected as control. Some of the tested compounds, compound 12c in particular, showed more active against three selected strains than the standard.