92823-43-3

Usage

Uses

Used in Sensor Fabrication:
6-Mercaptonicotinic acid is used as a key component in the fabrication of nanowell-based sensors for the detection of improvised explosive devices (IEDs). Its unique chemical properties enable the development of highly sensitive and selective sensors for security applications.
Used in Gold Nanoparticle Functionalization:
In the field of analytical chemistry, 6-Mercaptonicotinic acid is used for the functionalization of gold nanoparticles (AuNPs). This allows for the highly sensitive and selective detection of Cd2+ ions in colorimetric assays, which is crucial for environmental monitoring and public health.
Used in Thiolated Chitosan Preparation:
6-Mercaptonicotinic acid is utilized in the preparation of thiolated chitosans, which are thiolated biopolymers exhibiting mucoadhesive, enzyme inhibitory, and permeation-enhancing properties. These biopolymers have potential applications in the pharmaceutical and biomedical industries, such as drug delivery and tissue engineering.
Used in Coordination Polymer Synthesis:
6-Mercaptonicotinic acid is also employed in the synthesis of Zinc(II) coordination polymers. These polymers have potential applications in various fields, including catalysis, gas storage, and molecular recognition, due to their unique structural and functional properties.

InChI:InChI=1/C6H5NO2S/c8-6(9)4-1-2-5(10)7-3-4/h1-3H,(H,7,10)(H,8,9)

Upstream product

• 15658-35-2 6,6'-dithionicotinic acid 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 

Downstream Products

• 74470-40-9 2-methylthiopyridine-5-carboxylic acid methyl ester 
• 1240495-79-7 C₂₀H₁₆BFN₂O₅S 
• 1240494-25-0 6-(2-hydroxy-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide 
• 1240555-92-3 C₁₈H₁₂FN₃O₅S 
• 1240495-92-4 6-(2-boronic pinacol ester-5-methoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)nicotinamide 
• 1240494-16-9 6-(2-boronic acid-5-methoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide 
• 1240495-91-3 6-(2-bromo-5-methoxy-benzylsulfanyl)-N-(4-fluorophenyl)-nicotinamide 
• 1240494-14-7 6-(2-boronic acid-5-trifluoromethoxybenzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide 
• 1240494-30-7 6-(2-boronicpinacol ester-5-trifluromethoxy-benzylsulfanyl)-N-(4-fluoro-phenyl)-nicotinamide 
• 1240494-93-2 N-(4-fluorophenyl)-6-(2-oxotetrahydrofuran-3-ylthio)nicotinamide 
• 1240494-60-3 6-((2H-tetrazol-5-yl)methylthio)-N-(4-fluorophenyl)nicotinamide 
• 1240494-27-2 N-(4-fluorophenyl)-6-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylthio)nicotinamide 
• 1240494-13-6 2-[5-(4-fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic acid 
• 1240494-38-5 6-(3,4-dichlorobenzylthio)-N-(4-fluorophenyl)nicotinamide 

Relevant academic research and scientific papers

CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Tetracyclic benzimidazole derivatives and combinatorial libraries thereof

The present invention relates to novel tetracyclic benzimidazole derivative compounds of the following formula: wherein R1to R10have the meanings described in here. The invention further relates to combinatorial libraries containing two or more such compounds, as well as methods of preparing tetracyclic benzimidazole derivative compounds.

The reduction of specific disulfides with titanium(III) chloride

The reaction between titanium(III) chloride and disulfides was investigated.Aryl and alkyl disulfides did not react while heterocyclic aromatic disulfides with a nitrogen α to the sulfur were reduced to the corresponding thiols.Products were identified and characterized by nuclear magnetic resonance and inrared spectra; and melting point comparisons with authentic compounds.The reductions occurred only in the presence of citrate and were found to require 2 moles of titanium(III) per mole of disulfide.