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Usage

Uses

Used in Pharmaceutical Research:
3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine is utilized as a research tool for studying the sigma-1 receptor, which is involved in various neurological functions. Its selectivity for this receptor makes it valuable in exploring the receptor's role in neurodegenerative diseases and potential drug development.
Used in Neurodegenerative Disease Treatment:
In the field of neurology, 3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine is considered for its potential therapeutic effects in treating neurodegenerative conditions such as Alzheimer's and Parkinson's disease. Its interaction with the sigma-1 receptor suggests a possible avenue for symptom management or disease modification.
Used in Oncology Research:
3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine is also being investigated for its potential use in cancer treatment. Its role as a sigma-1 receptor ligand may offer insights into cancer biology and the development of novel therapeutic strategies targeting this receptor in oncological applications.
Used in Psychiatric Disorder Research:
In the psychiatric field, 3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine serves as a compound of interest for studying the sigma-1 receptor's involvement in psychiatric disorders. Understanding its interaction with the receptor may pave the way for new treatments or therapeutic approaches for mental health conditions.
Overall, 3-Iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine, or IMPY, is a versatile compound with applications spanning across different areas of medical and scientific research, particularly in the realms of neurology, oncology, and psychiatry. Its role as a selective sigma-1 receptor ligand positions it as a key player in the development of future therapeutics and a deepening understanding of receptor biology.

InChI:InChI=1/C8H7IN2O/c1-12-6-2-3-10-8-7(6)5(9)4-11-8/h2-4H,1H3,(H,10,11)

Upstream product

• 122379-63-9 4-methoxy-1H-pyrrolo<2,3-b>pyridine 
• 1254926-83-4 tert-butyl 3-iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine-1-carboxylate 

Downstream Products

• 1254926-42-5 3-(1-benzyl-1H-1,2,3-triazol-4-yl)-4-methoxy-1H-pyrrolo[2,3-b]pyridine 
• 1254926-84-5 C₂₂H₂₃N₅O₃ 

Relevant academic research and scientific papers

Sequentially Catalyzed Three-Component Masuda-Suzuki-Sonogashira Synthesis of Fluorescent 2-Alkynyl-4-(7-azaindol-3-yl)pyrimidines: Three Palladium-Catalyzed Processes in a One-Pot Fashion

The Masuda-Suzuki-Sonogashira sequence efficiently unites, in a one-pot fashion, a borylation, an arylation, and an alkynylation in the sense of a sequentially Pd-catalyzed three-component reaction to give fluorescent 2-alkynyl-4-(7-azaindol-3-yl) pyrimid

Painting argyrins blue: Negishi cross-coupling for synthesis of deep-blue tryptophan analogue β-(1-azulenyl)-L alanine and its incorporation into argyrin C

The argyrins are a family of non-ribosomal peptides that exhibits different biological activities through only small structural changes. Ideally, a biologically active molecule can be tracked and observed in a variety of biological and clinical settings in a non-invasive manner. As a step towards this goal, we report here a chemical synthesis of unnatural deep blue amino acid β-(1-azulenyl)-L alanine with different fluorescence and photophysical properties, which allows a spectral separation from the native tryptophan signal. This might be especially useful for cell localization studies and visualizing the targeted proteins. In particular, the synthesis of β-(1-azulenyl)-L alanine was achieved through a Negishi coupling which proved to be a powerful tool for the synthesis of unnatural tryptophan analogs. Upon β-(1-azulenyl)-L alanine incorporation into argyrin C, deep blue octapeptide variant was spectrally and structurally characterized.

3-(1,2,3-Triazol-4-yl) pyrrolo [2,3-b] pyridine derivatives

Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in claim (1), are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.