928663-69-8Relevant academic research and scientific papers
Design driven HtL: The discovery and synthesis of new high efficacy β2-agonists
Stocks, Michael J.,Alcaraz, Lilian,Bailey, Andrew,Bonnert, Roger,Cadogan, Elaine,Christie, Jadeen,Connolly, Stephen,Cook, Anthony,Fisher, Adrian,Flaherty, Alice,Hill, Stephen,Humphries, Alexander,Ingall, Anthony,Jordan, Stephen,Lawson, Mandy,Mullen, Alex,Nicholls, David,Paine, Stuart,Pairaudeau, Garry,St-Gallay, Stephen,Young, Alan
scheme or table, p. 4027 - 4031 (2011/08/06)
The design and synthesis of a new series of high efficacy β2-agonists devoid of the key benzylic alcohol present in previously described highly efficacious β2-agonists is reported. A hypothesis for the unprecedented level of efficacy is proposed based on considerations of β2-adrenoceptor crystal structure, other biophysical data and modeling studies.
AMINE DERIVATIVES AND THEIR USE IN BETA-2-ADRENORECEPTOR MEDIATED DISEASES
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Page/Page column 55, (2008/12/06)
The present invention provides compounds of formula (I), wherein k, Ar, R2, R3, R4, R5, R4', R5', R6, R7, A, D, m and E are as defined in the specification, processes
7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS
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Page/Page column 45, (2008/06/13)
The present invention provides compounds of formula (I) wherein e, R1, R2, R3, R4, R5, R4', R5', R6, R7, A, D, m and n are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
