928673-13-6

Basic information

• Product Name: 2,2-dimethyl-propionic acid 3-[3-(3-chloro-5-methoxy-4-methoxymethoxy-benzyl)-thioureido]-2-(3,4-dimethyl-benzyl)-propyl ester
• CAS NO: 928673-13-6
• Molecular Weight: 551.147
• Mol File: 928673-13-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,2-dimethyl-propionic acid 3-[3-(3-chloro-5-methoxy-4-methoxymethoxy-benzyl)-thioureido]-2-(3,4-dimethyl-benzyl)-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dimethyl-propionic acid 3-[3-(3-chloro-5-methoxy-4-methoxymethoxy-benzyl)-thioureido]-2-(3,4-dimethyl-benzyl)-propyl ester(928673-13-6)
• EPA Substance Registry System: 2,2-dimethyl-propionic acid 3-[3-(3-chloro-5-methoxy-4-methoxymethoxy-benzyl)-thioureido]-2-(3,4-dimethyl-benzyl)-propyl ester(928673-13-6)

Safety Data

• Hazardous Substances Data: 928673-13-6(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 19463-48-0 5-chlorovanillin 
• 926888-94-0 5-azidomethyl-1-chloro-3-methoxy-2-methoxymethoxy-benzene 
• 926888-93-9 (3-chloro-5-methoxy-4-methoxymethoxy-phenyl)-methanol 
• 926888-92-8 3-chloro-5-methoxy-4-methoxymethoxy-benzaldehyde 
• 926888-97-3 1-chloro-5-isothiocyanatomethyl-3-methoxy-2-methoxymethoxy-benzene 
• 401573-58-8 N-[2-(3,4-dimethylbenzyl)-3-pivaloyloxy-propyl]hydroxylamine 

Relevant articles and documents

Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin

Selected potent TRPV1 agonists (1-6) have been modified by 5- or 6-halogenation on the aromatic A-region to analyze their effects on potency and efficacy (agonism versus antagonism). The halogenation caused enhanced functional antagonism at TRPV1 compared to the corresponding prototype agonists. The analysis of SAR indicated that the antagonism was enhanced as the size of the halogen increased (I > Br > Cl) and when the 6-position was halogenated. Compounds 23c and 31b were found to be potent full antagonists with Ki (as functional antagonist) = 23.1 and 30.3 nM in rTRPV1/CHO system, respectively.