19463-48-0

Basic information

• Product Name: 5-CHLOROVANILLIN
• Synonyms: 3-CHLORO-4-HYDROXY-5-METHOXYBENZALDEHYDE;5-CHLOROVANILLIN;5-CHLORO-4-HYDROXY-3-METHOXYBENZALDEHYDE;AKOS B004155;AKOS BBS-00006984;OTAVA-BB BB7020410012;3-chlorovanillin;3-CHLORO-4-HYDROXY-5-METHOXYBENZALDEHYD&
• CAS NO: 19463-48-0
• Molecular Formula: C₈H₇ClO₃
• Molecular Weight: 186.59
• EINECS: 243-086-7
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;C8;Carbonyl Compounds
• Mol File: 19463-48-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 165-169 °C(lit.)
• Boiling Point: 266.91°C (rough estimate)
• Flash Point: 128 °C
• Appearance: WHITE TO GREY POWDER OR CRYSTALS
• Density: 1.3245 (rough estimate)
• Vapor Pressure: 0.00138mmHg at 25°C
• Refractive Index: 1.5250 (estimate)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.32±0.23(Predicted)
• CAS DataBase Reference: 5-CHLOROVANILLIN(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLOROVANILLIN(19463-48-0)
• EPA Substance Registry System: 5-CHLOROVANILLIN(19463-48-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 19463-48-0(Hazardous Substances Data)

Usage

Uses

The product has been used for an oxidation reaction by laccase to form hydroxymethine quinone.

InChI:InChI=1/C8H7ClO3/c1-12-7-3-5(4-10)2-6(9)8(7)11/h2-4,11H,1H3

Upstream product

• 507-40-4 tert-butylhypochlorite 
• 121-33-5 vanillin 
• 67-66-3 chloroform 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 
• 20624-92-4 3-chloro-4-hydroxy-5-methoxy-benzyl alcohol 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 7782-50-5 chlorine 
• 18268-80-9 2-chloro-6-methoxy-4-methylphenol 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 18268-68-3 5-chloroveratraldehyde 
• 182345-46-6 5,5-Dimethyl-2-(4-hydroxy-3-methoxyphenyl)-1,3-dioxane 
• 302321-78-4 4-(5,5-dimethyl-[1,3]dioxan-2-yl)-6,6-dimethoxy-cyclohexa-2,4-dienone 

Downstream Products

• 20624-92-4 3-chloro-4-hydroxy-5-methoxy-benzyl alcohol 
• 62936-23-6 3-chloro-4-hydroxy-5-methoxybenzoic acid 
• 5438-40-4 5-CFA 
• 54490-80-1 2-chloro-6-methoxy-p-benzoquinone 
• 179795-11-0 2-chloro-6-methoxy-hydroquinone 
• 37687-67-5 3-chloro-5-(methyloxy)-4-[(phenylmethyl)oxy]benzaldehyde 

Relevant articles and documents

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IMIDAXOPYROLONE COMPOUND AND APPLICATION THEREOF

Disclosed is a novel class of MDM2-p53 inhibitor compounds having an imidaxopyrolone structure, and specifically disclosed are compounds represented by formulas (I-1) and (I-2) and pharmaceutically acceptable salts thereof. (I-1), (I-2)

Unanticipated participation of HCl in nucleophilic chlorination reaction: Expedient route to meta chlorophenols

o-Quinone monoketals participated in a 1,4-addition reaction with HCl furnishing m-chlorophenols in high yields. Several readily available o-quinone monoketals were selected to display the generality of this serendipitous and unprecedented reaction and the results are presented herein.