929-25-9

Usage

Physical state

Clear, colorless liquid at room temperature

Uses

Raw material in the production of polyurethane foams and elastomers

Reactivity

Highly reactive due to isocyanate functional groups

Health hazards

Can cause irritation to skin, eyes, and respiratory system upon contact or inhalation

Toxicity

Considered toxic if ingested

Health effects

Can cause serious health effects if not handled properly

Safety

Should be handled with caution and in accordance with proper safety protocols

Upstream product

• 50326-52-8 NN'-diformyl-1,4-diaminobutane 

Downstream Products

• 73442-13-4 3-(5-Phenyloxazol-4-yl)propylisocyanid 
• 73442-16-7 5,5'-Diphenyl-4,4'-ethylenbis(oxazol) 
• 73442-10-1 1-Benzyl-1,4-butylendiisocyanid 
• 73442-15-6 1,4-Dibenzyl-1,4-butylendiisocyanid 
• 73442-12-3 <4-(3-Isocyanpropyl)-5,5-dimethyl-2-oxazolin-2-yl>diphenylmethanol 
• 1571103-87-1 tert-butyl 10,17-dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosane-1,26-diyldicarbamate 
• 73442-11-2 <4-(3-Isocyanpropyl)-5,5-diphenyl-2-oxazolin-2-yl>diphenylmethanol 

Relevant academic research and scientific papers

On the scope of the double Ugi multicomponent stapling to produce helical peptides

The stabilization of helical structures by peptide stapling approaches is now a mature technology capable to provide a variety of biomedical applications. Recently, it was shown that multicomponent macrocyclization is not only an effective way to introduc

Transition metal complex catalysts

Substrates are oxidized by means of two-oxidative addition reactions of a dimeric, dinuclear transition metal complex oxidant containing four binucleating diisocyanide bridge ligands. The complex is reoxidized by means of a secondary oxidant which is a stronger oxidizing agent than the complex which in turn is oxidized by molecular oxygen. Though the direct oxidation of the complex by oxygen involves a large energy barrier and is relatively slow, the kinetics of the two stage oxidation of the complex by the secondary oxidant and of the oxidant by oxygen permit regeneration of the oxidant at reasonable rate. Substrates, such as the olefins, ethylene or propylene, have been continuously oxidized by bubbling oxygen and the olefin through a solution of a dimeric, dirhodium complex containing four 1,3-diisocyanopropane bridge ligands and a secondary oxidant such as a cerium salt.

Reaction of Bidentate Isonitrile Ligands with Iron Carbonyls

Reaction of the bidentate isonitriles CN(CH2)nNC ( n =2, 3, 4, or 6) with (cp = η-cyclopentadienyl) yields exclusively 2> derivatives which are fluxional in solution and exist in three isomeric forms (bridged-bridged, bridged-terminal, and terminal-terminal with respect to the bonding mode of the bidentate isonitrile).The proportion of the isomers containing terminally bound isonitrile increases with the length of the alkyl chain.The complexes may be protonated to yield 2>2 salts (n = 2 or 6) and may be cleaved with I2 to give and 2nNC>> (n = 2 or 6).Reaction ofCN(CH2)nNC (n = 2 or 6 with or yields exclusively 2nNC>>

Synthesis with α-Metalated Isocyanides, XLIII. - Experiments with Lithiated α,ω-Alkylene Diisocyanides

1,2-Ethylene diisocyanide (4a) reacts with two equivalents of butyllithium (-100 deg C) to give 1,1-dilithio-1,2-ethylene diisocyanide (7) which with ketones yields the oxazines 11. - 1,3-Propylene diisocyanide (4b) reacts with one equivalent butyllithium (-70 deg C) to furnish 1-lithio-1,3-propylene diisocyanide (12) which cyclizes to afford 3-lithio-1-pyrrolin-3-yl isocyanide (14).With ketones, chlorotrimethylsilane, and epoxides 14 furnishes the compounds 17-19 and 21. - 1,4-Butylene diisocyanide (4c) reacts (-100 deg C) with one equivalent butyllithium to give 1-lithio-1,4-butylene diisocyanide (23), and with two equivalents to give 1,4-dilithio-1,4-butylene diisocyanide (28).Both compounds are thermolabile, but can be trapped by electrophils which react below -60 deg C.