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INDOLECARBOXYLIC ACID DERIVATIVE HAVING PGD2 RECEPTOR ANTAGONISTIC ACTIVITY
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Page/Page column 67, (2008/06/13)
Indolecarboxylic acid derivatives having DP receptor antagonistic activity and pharmaceutical compositions containing the compounds as active ingredients; and further relevant therapeutic agents for allergic diseases. There are provided compounds, their pharmaceutically acceptable salts or solvates thereof, the compounds represented by the general formula: (I) wherein the ring A is an aromatic carbon ring, etc.; the ring B is a nonaromatic-nitrogen-containing heterocycle, etc.; the formula -X1=X2-X3=X4- is the formula -C(R1)=C(R2)-C(R3)=C(R4)-, etc.; X5 is C(R5) or N; each of R1, R2, R3, R4 and R5 independently is a hydrogen atom, a halogen atom, etc.; R6 is the formula -Z-R10 (in which Z is alkylene, etc.; and R10 is carboxyl, etc.), etc.; R7 is an optionally substituted alkyloxy, etc.; each of R8s independently is a halogen atom, etc.; each of R9s independently is an optionally substituted alkyl, etc.; Y is a single bond, etc.; n is 0, etc.; and q is 0, etc.
