98995-40-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Isopropoxybenzenesulfonyl chloride is used as a reagent for the synthesis of sulfonamides, which are a class of compounds with broad-spectrum antimicrobial properties. These sulfonamides are employed as antibiotics in the treatment of various bacterial infections.
Used in Organic Synthesis:
4-Isopropoxybenzenesulfonyl chloride is used as a protecting group for alcohols and amines during organic synthesis. This function is crucial in preventing unwanted side reactions, thereby ensuring the desired product formation and improving the overall yield of the synthesis process.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Isopropoxybenzenesulfonyl chloride is utilized for the introduction of the sulfonyl chloride functional group into various drug molecules. This modification can enhance the pharmacological properties of the compounds, such as their solubility, stability, and bioavailability, ultimately contributing to the development of more effective therapeutic agents.
Used in Controlled Laboratory Settings:
Due to its high reactivity and potential hazards, 4-Isopropoxybenzenesulfonyl chloride is used with caution in controlled laboratory settings. This ensures the safety of researchers and the integrity of the experimental procedures, minimizing the risk of accidents and unwanted reactions.

InChI:InChI=1/C9H11ClO3S/c1-7(2)13-8-3-5-9(6-4-8)14(10,11)12/h3-7H,1-2H3

Upstream product

• 825-90-1 sodium p-hydroxybenzenesulfonate 

Downstream Products

• 929005-90-3 C₁₃H₁₉NO₄S 
• 1426153-20-9 C₂₇H₄₂N₂O₃S 
• 1426151-84-9 N-benzyl-N-(4-(diethylamino)benzyl)-4-isopropoxybenzenesulfonamide 
• 1194061-56-7 (+/-)-3-(2-fluorophenyl)-1-[(4-isopropoxyphenyl)sulphonyl]-5-methoxy-3-(4-piperazin-1-ylbutyl)-1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one 
• 1182403-04-8 tert-butyl 4-[3-[5-chloro-3-(2-fluorophenyl)-1-[(4-isopropoxyphenyl)-sulfonyl]-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]piperazine-1-carboxylate 
• 1182402-98-7 N-[(1R)-[3-[5-chloro-3-(2-fluorophenyl)-1-[(4-isopropoxyphenyl)sulfonyl]-6-methoxy-2-oxo-2,3-dihydro-1H-indol-3-yl]propyl]pyrrolidin-3-yl]-2,2,2-trifluoroacetamide 
• 1188355-33-0 5-Chloro-3-(3-chloropropyl)-3-(2-fluorophenyl)-6-methoxy-1-{[4-(1-methyl-ethoxy)phenyl]sulfonyl}-1,3-dihydro-2H-indol-2-one 
• 881678-90-6 1-{1-[(4-isopropoxyphenyl)sulfonyl]-5-phenyl-1H-pyrrol-3-yl}-N-methylmethanamine 
• 932372-92-4 C₂₀H₂₃NO₄S 
• 921196-64-7 C₂₇H₃₉N₃O₄SSi 

Relevant academic research and scientific papers

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors

Atrial fibrillation (AF) is one of the common arrhythmias that threaten human health. Kv1.5 potassium channel is reported as an efficacious and safe target for the treatment of AF. In this paper, we designed and synthesized three series of compounds through modifying the lead compound RH01617 that was screened out by the pharmacophore model we reported earlier. All of the compounds were evaluated by the whole-patch lamp technology and most of them possessed potent inhibitory activities against Kv1.5. Compounds IIIi and IIIl were evaluated for the target selectivity as well as the pharmacodynamic effects in an isolated rat model. Due to the promising pharmacological behavior, compound IIIl deserves further pharmacodynamic and pharmacokinetic evaluations.