929042-18-2Relevant academic research and scientific papers
Discovery of novel triazole-based opioid receptor antagonists
Zhang, Qiang,Keenan, Susan M.,Peng, Youyi,Nair, Anil C.,Yu, Seong Jae,Howells, Richard D.,Welsh, William J.
, p. 4044 - 4047 (2007/10/03)
We report the computer-aided design, chemical synthesis, and biological evaluation of a novel family of δ opioid receptor (DOR) antagonists containing a 1,2,4-triazole core structure that are structurally distinct from other known opioid receptor active l
Efficient new approach for the synthesis of N,N-dialkylamino-1,2,4-triazoles
Zhang, Qiang,Peng, Youyi,Welsh, William J.
, p. 2635 - 2645 (2008/02/04)
A series of 3-NN-dialkylamino-4,5-diaryl-1,2,4-triazoles were synthesized in high yield under mild reaction conditions by coupling functionalized arylmagnesiums with isothiocyanates and cyclization with Viehe's salts. No selective thionation reaction was
