929048-82-8

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 124-38-9 carbon dioxide 
• 676147-57-2 N'-(3,5-dimethoxybenzylidene)-4-methylbenzenesulfonylhydrazide 
• 108-98-5 thiophenol 
• 187752-49-4 (R,S)3,5-dimethoxymandelic acid 
• 158692-40-1 methyl 2-(3,5-dimethoxyphenyl)-2-bromoacetate 

Downstream Products

• 929048-86-2 N-(3-methoxybenzyl)-N-methyl-2-(3,5-dimethoxyphenyl)-2-(phenylsulfinyl)-acetamide 
• 929048-84-0 N-(3-methoxybenzyl)-N-methyl-2-(3,5-dimethoxyphenyl)-2-(phenylsulfanyl)-acetamide 

Relevant academic research and scientific papers

Umpolung Difunctionalization of Carbonyls via Visible-Light Photoredox Catalytic Radical-Carbanion Relay

The combination of photoredox catalysis with the Wolff-Kishner (WK) reaction allows the difunctionalization of carbonyl groups by a radical-carbanion relay sequence (photo-Wolff-Kishner reaction). Photoredox initiated radical addition to N-sulfonylhydrazones yields α-functionalized carbanions following the WK-type mechanism. With sulfur-centered radicals, the carbanions are further functionalized by reaction with electrophiles including CO2 and aldehydes, whereas CF3 radical addition furnishes a wide range of gem-difluoroalkenes through β-fluoride elimination of the generated α-CF3 carbanions. More than 80 substrate examples demonstrate the broad applicability of this reaction sequence. A series of investigations including radical inhibition, deuterium labeling, fluorescence quenching, cyclic voltammetry, and control experiments support the proposed radical-carbanion relay mechanism.

Isoquinolines as IGF-1R Inhibitors

Compounds of the formula (I): were synthesized. In at least one embodiment, they were found to down-regulate or inhibit the expression or function of the IGF-1 receptor.

ISOQUINOLINES AS IGF-1R INHIBITORS

Compounds of the formula (I) were synthesized. They were found to down- regulate or inhibit the expression or function of the IGF-I receptor.