929095-69-2

Basic information

• Product Name: methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{[5-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrophenyl]amino}-2-thiophenecarboxylate
• Synonyms: methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{[5-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrophenyl]amino}-2-thiophenecarboxylate
• CAS NO: 929095-69-2
• Molecular Weight: 569.035
• Mol File: 929095-69-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{[5-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrophenyl]amino}-2-thiophenecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{[5-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrophenyl]amino}-2-thiophenecarboxylate(929095-69-2)
• EPA Substance Registry System: methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-{[5-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrophenyl]amino}-2-thiophenecarboxylate(929095-69-2)

Safety Data

• Hazardous Substances Data: 929095-69-2(Hazardous Substances Data)

Upstream product

• 929095-68-1 2-bromo-4-({[4-(methyloxy)phenyl]methyl}oxy)-2-nitrobenzene 
• 929039-97-4 methyl 5-amino-3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate 
• 929040-00-6 methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-nitro-2-thiophenecarboxylate 

Downstream Products

• 929095-70-5 methyl 5-{[2-amino-5-({[4-(methyloxy)phenyl]methyl}oxy)-phenyl]amino}-3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-2-thiophenecarboxylate 

Relevant articles and documents

Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

A series of thiophene PLK1 inhibitors was optimized for increased solubility and reduced protein binding through the appendage of basic amine functionality. Interesting selectivity between PLK1 and PLK3 was also obtained through these modifications.

REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES

The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.