929100-66-3 Usage
Uses
Used in Pharmaceutical Industry:
N-DesMethyl ent-Tadalafil is used as an intermediate in the synthesis of novel potent arylated analogues of tadalafil (T004500) for the development of new and improved pharmaceutical compounds. Its role in the synthesis process is essential in creating innovative and effective treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 929100-66-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,1,0 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 929100-66:
(8*9)+(7*2)+(6*9)+(5*1)+(4*0)+(3*0)+(2*6)+(1*6)=163
163 % 10 = 3
So 929100-66-3 is a valid CAS Registry Number.
929100-66-3Relevant academic research and scientific papers
Beghyn, Terence,Hounsou, Candide,Deprez, Benoit P.
, p. 789 - 792 (2007)
A method to access totally new analogues of tadalafil was explored. The Buchwald reaction was adapted and used to replace the methyl group of tadalafil by various aryl groups. Inhibition potencies on PDE5 of these analogues were determined and proved to be comparable to the one of tadalafil. Using the same route, compounds with the same level of activity but improved water solubility were produced by introducing a pyridine or a pyrimidine ring. This original route also opens access to new unpatented compounds.
