929200-52-2Relevant academic research and scientific papers
Synthesis of Orthogonal N-Protected C-Functional Side-Bridged Cyclams to Give Access to Unsymmetrical Constrained BCAs
Le Bihan, Thomas,Le Bris, Nathalie,Bernard, Hélène,Platas-Iglesias, Carlos,Tripier, Rapha?l
, p. 5955 - 5962 (2019)
Considering the current importance of unsymmetrical mono- and di-N-functionalized ethylene side-bridged (sb) cyclams and the need to have their C-appended derivatives bearing an additional function dedicated to a conjugation to an external moiety as a targeting biomolecule, we have developed a general procedure to obtain orthogonally N-protected sb-cyclams with a benzyl or a Boc group. Despite the lack of symmetry of the compounds, this methodology allows the specific protection of one or the other remaining secondary amine function.
Synthesis of Piperazinocyclams by Reductive Ring Cleavage of mono-Quaternary Salts of cis-Perhydro-3a,5a,8a,10a-tetraazapyrene
Kolinski, Ryszard A.
, p. 1039 - 1045 (2007/10/02)
5-Alkylpiperazinocyclams (9a,9b) have been obtained by reductive ring cleavage of mono-methiodide or mono-benzyl bromide of cis-perhydrotetraazapyrene (6a,6b) with NaBH4. 5,8-Dimethylpiperazinocyclam (11) was obtained by methylation (formaline/NaBH3CN) of
