929249-82-1

Usage

Uses

Used in Pharmaceutical Industry:
2-chloro-1-(2,3-difluorophenyl)ethanone serves as a crucial intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of a wide range of medicinal compounds with diverse applications in healthcare.
Used in Agrochemical Industry:
In the agrochemical sector, 2-chloro-1-(2,3-difluorophenyl)ethanone is utilized as an intermediate for the production of various agrochemicals, including pesticides and herbicides. Its incorporation into these products helps enhance their effectiveness in controlling pests and weeds, thereby supporting agricultural productivity.
Used as a Building Block in Organic Synthesis:
Beyond its applications in pharmaceuticals and agrochemicals, 2-chloro-1-(2,3-difluorophenyl)ethanone also functions as a versatile building block in the synthesis of a variety of organic compounds. Its reactivity and structural features make it a valuable component in the creation of complex organic molecules for various industrial and research purposes.

Upstream product

• 79-04-9 chloroacetyl chloride 
• 367-11-3 ortho-difluorobenzene 
• 886762-77-2 2-bromo-1-(2,3-difluorophenyl)ethane-1-one 
• 18355-80-1 2,3-difluoroacetophenone 

Downstream Products

• 953081-38-4 C₁₀H₉ClF₂O 
• 953077-40-2 N-{(3Z)-4-(2,3-difluorophenyl)-1,1-dipropionyl-5-[(2,2,2-trifluoroethyl)amino]pent-3-en-1-yl}acetamide 
• 1056937-38-2 C₂₀H₂₅F₂NO₈S 
• 953083-87-9 C₁₈H₂₁F₅N₂O₃ 
• 953077-39-9 N-[(3Z)-4-(2,3-difluorophenyl)-5-hydroxy-1,1-dipropionylpent-3-en-1-yl]acetamide 
• 953081-41-9 N-[6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)-2,3,4,7-tetrahydro-1H-azepin-3-yl]acetamide 
• 953077-41-3 C₁₄H₁₃F₅N₂O 
• 953077-38-8 2-(2,3-difluorophenyl)-2-vinyloxirane 
• 308368-71-0 [2-(4-{4-[4-(2,3-difluoro-phenyl)-thiazol-2-yl]-benzenesulfonylamino}-phenyl)-ethyl]-(2-hydroxy-2-pyridin-3-yl-ethyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

FLUOROPHENYL BETA-HYDROXYETHYLAMINES AND THEIR USE IN THE TREATMENT OF HYPERGLYCAEMIA

There is herein provided a compound of formula (I).

Process for the preparation of Caprolactam Cgrp Antagonist

An efficient syntheses for the preparation of (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one.

PROCESS FOR THE PREPARATION OF CGRP ANTAGONIST

An efficient synthesis for the preparation of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine -1-carboxamide, by coupling (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one and 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride with 1,1''-carbonyldiimidazole (""CDI"") as carbonyl source; and an efficient preparation of the potassium salt of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine -1-carboxamide.

PROCESS FOR THE PREPARATION OF PYRIDINE HETEROCYCLE CGRP ANTAGONIST INTERMEDIATE

An efficient syntheses for the preparation of the intermediate 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride, and other salt forms of 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine.

CGRP ANTAGONIST SALT

An efficient synthesis for the preparation of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine -1-carboxamide, by coupling (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one and 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride with 1,1'-carbonyldiimidazole ("CDI") as carbonyl source; an efficient preparation of the potassium salt of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine -1-carboxamide; efficient syntheses for the preparation of intermediates (3R,6S)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one and 2-oxo-1-(4-piperidinyl)-2,3-dihydro-1H-imidazo[4,5-b]pyridine dihydrochloride, and the potassium salt of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine -1-carboxamide including the potassium salt ethanolate and potassium salt hydrate.

One-step synthesis of α-Chloro acetophenones from acid chlorides and Aryl precursors

A direct and efficient method was developed for the preparation of a variety of substituted acetophenone derivatives from readily available arene precursors and acid chlorides. This method has significant generality and affords access to substitution patt