929258-59-3Relevant academic research and scientific papers
Substituted tricyclic piperidone compounds
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Page/Page column 5; 6, (2009/01/24)
Substituted tricyclic piperidone derivatives corresponding to Formula I: a method for producing such compounds; pharmaceutical compositions containing such compounds, and the use of such compounds to treat pain, depression, urinary incontinence, diarrhea, pruritus, alcohol and drug abuse, drug dependency, lethargy and/or anxiety.
Synthesis of benzomorphan analogues by intramolecular Buchwald-Hartwig cyclization
Khartulyari, Anton S.,Maier, Martin E.
, p. 317 - 324 (2007/10/03)
A new strategy toward the important class of benzomorphans is described. The key bond formation is based on an intramolecular Buchwald-Hartwig enolate arylation reaction. Thus, alkylation of piperidones with ortho-bromobenzyl bromides provides the necessary substrates. In the presence of a palladium catalyst, a sterically hindered phosphane ligand, and a base, carbon-carbon bond formation to tricyclic benzomorphan derivatives takes place. After removal of the N-protecting group, derivatization reactions are possible. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
