929294-62-2

Basic information

• Product Name: Fmoc-Thr(tBu)-NHBn
• CAS NO: 929294-62-2
• Molecular Weight: 486.611
• Mol File: 929294-62-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Fmoc-Thr(tBu)-NHBn(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-Thr(tBu)-NHBn(929294-62-2)
• EPA Substance Registry System: Fmoc-Thr(tBu)-NHBn(929294-62-2)

Safety Data

• Hazardous Substances Data: 929294-62-2(Hazardous Substances Data)

Upstream product

• 71989-35-0 Fmoc-Thr(tBu)-OH 
• 100-46-9 benzylamine 

Downstream Products

• 1349173-29-0 Ac-Phe-Thr(tBu)-NHBn 
• 1349173-28-9 Fmoc-Phe-Thr(tBu)-NHBn 
• 1349173-05-2 Ac-Phe-Thr-NHBn 
• 817167-11-6 NH₂-Thr(t-Bu)-NHBn 
• 929294-64-4 Fmoc-Thr(CO₂-nitrophenyl)-NHBn 
• 929294-63-3 Fmoc-Thr-NHBn 

Relevant articles and documents

Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics

O-Carbamoylserine and O-carbamoylthreonine are glutamine analogues that were incorporated into a Stat3 inhibitory peptide to probe the requirements of Gln at the pY+3 position. Fmoc-Ser-NHBn and Fmoc-Thr-NHBn were converted to nitrophenyl carbonates and were attached to Rink resin via a side-chain carbamate linkage. After assembly of the peptide, acid treatment resulted in O-carbamoylserine and O-carbamoylthreonine-containing peptides. The order of affinity for Stat3 was Gln > Ser(CONH2) ? Thr(CONH2) suggesting a relatively tight binding pocket for the side chain of glutamine.