92936-36-2

Upstream product

• 92838-29-4 (1S,2S,3R)-3-Isocyano-cyclohexane-1,2-diol 
• 92838-29-4 (1R,2S,3R)-3-Isocyano-cyclohexane-1,2-diol 

Relevant academic research and scientific papers

NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS

The invention provides novel compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation.(Formula I)

DIRECTIVE EFFECTS IN THE OPENING OF EPOXIDES WITH TRIMETHYLSILYL CYANIDE- ZINC IODIDE. THE ESTABLISHMENT OF THREE CONTIGUOUS CHIRAL CENTERS.

Adjacent hydroxyl, trimethylsiloxyl, and acetoxyl groups have been shown to provide complete control over the regiospecifity of the opening of epoxides by trimethylsilyl cyanide - zinc iodide.Thus, cyclohex-2-en-R-1-ol can be readily converted into (1R,2S,3R)-3-aminocyclohexan-1,2-diol.