929411-71-2Relevant articles and documents
Design, synthesis and biological evaluation of novel 4-aminoquinazolines as dual target inhibitors of EGFR-PI3Kα
Ding, Huai-Wei,Deng, Cheng-Long,Li, Dan-Dan,Liu, Dan-Dan,Chai, Shao-Meng,Wang, Wei,Zhang, Yan,Chen, Kai,Li, Xin,Wang, Jian,Song, Shao-Jiang,Song, Hong-Rui
, p. 460 - 470 (2018/02/14)
The overexpression of EGFR correlates with rapidly progressive disease, resistance to chemotherapy and poor prognosis. In certain human cancers, PI3K works synergistically with EGFR to promote proliferation, survival, invasion and metastasis. Development
Synthesis and in vitro cytotoxicity of the 4-(Halogenoanilino)-6-bromoquinazolines and their 6-(4-fluorophenyl) substituted derivatives as potential inhibitors of epidermal growth factor receptor tyrosine kinase
Mphahlele, Malose Jack,Paumo, Hugues K.,Choong, Yee Siew
, (2017/12/05)
Series of the 2-unsubstituted and 2-(4-chlorophenyl)–substituted 4-anilino-6-bromoquinazolines and their 6-(4-fluorophenyl)–substituted derivatives were evaluated for in vitro cytotoxicity against MCF-7 and HeLa cells. The 2-unsubstituted 4-anilino-6-brom
Discovery, synthesis, and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors
Haffner, Curt D.,Becherer, J. David,Boros, Eric E.,Cadilla, Rodolfo,Carpenter, Tiffany,Cowan, David,Deaton, David N.,Guo, Yu,Harrington, Wallace,Henke, Brad R.,Jeune, Michael R.,Kaldor, Istvan,Milliken, Naphtali,Petrov, Kim G.,Preugschat, Frank,Schulte, Christie,Shearer, Barry G.,Shearer, Todd,Smalley, Terrence L.,Stewart, Eugene L.,Stuart, J. Darren,Ulrich, John C.
, p. 3548 - 3571 (2015/05/05)
A series of thiazoloquin(az)olinones were synthesized and found to have potent inhibitory activity against CD38. Several of these compounds were also shown to have good pharmacokinetic properties and demonstrated the ability to elevate NAD levels in plasm
Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5
Felts, Andrew S.,Saleh, Sam A.,Le, Uyen,Rodriguez, Alice L.,Weaver, C. David,Conn, P. Jeffrey,Lindsley, Craig W.,Emmitte, Kyle A.
scheme or table, p. 6623 - 6626 (2010/06/12)
A high-throughput cell-based screen identified a series of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of metabotropic glutamate receptor 5 (mGlu5). This Letter describes the SAR of this series and the profile of selected