92952-74-4

Upstream product

• 108761-49-5 acetic acid-(4-ethoxy-3-chloro-anilide) 
• 610-81-1 4-hydroxy-2-nitroaniline 
• 3964-52-1 2-chloro 4-aminophenol 
• 180330-54-5 water ethanol 

Downstream Products

• 92952-76-6 6-chloro-3-nitro-4-(γ-hydroxypropyl)aminophenol 
• 92952-75-5 6-chloro-3-nitro-4-(β-hydroxyethyl)aminophenol 
• 1421373-65-0 [N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)propen-2-amide] 

Relevant academic research and scientific papers

AZD9291 Intermediate and preparation method of AZD9291

The invention discloses AZD9291 intermediate and a preparation method of AZD9291. AZD9291 has a chemical name of N-{2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl}prop-2-enamide. The preparation method has a simple process, the raw material is easy to obtain and is economical and environmentally friendly, product yield and purity are high, the preparation method is easy to industrialize, lower in production cost and suitable for batch production, and the novel intermediate and the preparation method thereof are significant to AZD9291 economic techniques.

Substituted 4-amino-3-nitrophenols, processes for their preparation and hair-coloring agents containing these compounds

The invention relates to new 3-nitro-4-aminophenols of the formula (I) STR1 in which R denotes hydrogen or halogen, preferably chlorine or bromine, and R' denotes hydrogen or alkyl, hydroxyalkyl, dihydroxyalkyl or halogenohydroxyalkyl which has 1 to 6 car