929616-31-9Relevant academic research and scientific papers
Rh(III)-Catalyzed C?H Activation/Annulation of Aryl Hydroxamates with CF3-Containing α-Propargyl α-Amino Acid Derivatives
Vorobyeva, Daria V.,Petropavlovskikh, Dmitry A.,Godovikov, Ivan A.,Nefedov, Sergey E.,Osipov, Sergey N.
, p. 1883 - 1890 (2021/04/05)
A series of new orthogonally protected α-CF3-substituted α-amino carboxylates, and α-amino phosphonates decorated with pharmacophore isoquinolone core has been elaborated through the Rh(III)-catalyzed C?H activation/annulation of aryl hydroxamates with propargyl-containing α-amino acid derivatives and their phosphorus analogues.
Synthesis of α-Alkynyl-β,β,β-trifluoroalanine Derivatives by Sonogashira Cross-Coupling Reaction
Shchetnikov, Grigorii T.,Zotova, Maria A.,Bruneau, Christian,Dixneuf, Pierre H.,Osipov, Sergey N.
experimental part, p. 1587 - 1592 (2010/06/15)
An efficient route to new a-CF3-a-amino acid derivatives bearing an arylalkynyl moiety at the a-carbon atom has been developed. The method is based on palladium-catalyzed cross-coupling of the corresponding a-propargyl (ethynyl) a- amino esters
Ruthenium-catalyzed cyclotrimerization of 1,6- and 1,7-azadiynes: New access to fluorinated bicyclic amino acids
Shchetnikov, Grigorii T.,Osipov, Sergey N.,Bruneau, Christian,Dixneuf, Pierre H.
, p. 578 - 582 (2008/12/22)
An efficient access to a variety of trifluoromethyl-substituted cyclic α-amino acid derivatives based on ruthenium-catalyzed cyclotrimerization of appropriate 1,6- and 1,7-diynes with terminal and internal alkynes has been developed. Georg Thieme Verlag S
Effective pathway to the α-CF3-substituted azahistidine analogues
Shchetnikov, Grigorii T.,Peregudov, Alexander S.,Osipov, Sergej N.
, p. 136 - 140 (2008/03/13)
An efficient method for the preparation of functionalized α-trifluoromethyl-substituted azahistidine analogues has been developed. The method is based on the regioselective addition of allenylmagnesiumbromide to highly electrophilic imines of trifluoropyr
