929617-28-7 Usage
Uses
Used in Pharmaceutical Industry:
2-Bromo-4-ethyl-5-nitro-pyridine is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Bromo-4-ethyl-5-nitro-pyridine serves as a key intermediate in the production of agrochemicals. Its incorporation into these compounds can enhance their effectiveness in pest control and crop protection, thereby supporting agricultural productivity.
Used in Dye and Pigment Production:
2-Bromo-4-ethyl-5-nitro-pyridine is also employed in the manufacturing of dyes and pigments. Its chemical properties enable the creation of a wide range of colors and shades, finding applications in various industries such as textiles, plastics, and printing inks.
Check Digit Verification of cas no
The CAS Registry Mumber 929617-28-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,6,1 and 7 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 929617-28:
(8*9)+(7*2)+(6*9)+(5*6)+(4*1)+(3*7)+(2*2)+(1*8)=207
207 % 10 = 7
So 929617-28-7 is a valid CAS Registry Number.
929617-28-7Relevant academic research and scientific papers
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt
Zhu, Gui-Dong,Gong, Jianchun,Gandhi, Viraj B.,Woods, Keith,Luo, Yan,Liu, Xuesong,Guan, Ran,Klinghofer, Vered,Johnson, Eric F.,Stoll, Vincent S.,Mamo, Mulugeta,Li, Qun,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 2441 - 2452 (2007/10/03)
Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.
