929617-28-7

Basic information

• Product Name: 2-BroMo-4-ethyl-5-nitro-pyridine
• Synonyms: 2-BroMo-4-ethyl-5-nitro-pyridine
• CAS NO: 929617-28-7
• Molecular Formula: C₇H₇BrN₂O₂
• Molecular Weight: 231.04668
• Mol File: 929617-28-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-BroMo-4-ethyl-5-nitro-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BroMo-4-ethyl-5-nitro-pyridine(929617-28-7)
• EPA Substance Registry System: 2-BroMo-4-ethyl-5-nitro-pyridine(929617-28-7)

Safety Data

• Hazardous Substances Data: 929617-28-7(Hazardous Substances Data)

Usage

General Description

2-Bromo-4-ethyl-5-nitro-pyridine is a chemical compound with the molecular formula C7H7BrN2O2. It is a derivative of pyridine with a bromine and a nitro group attached to the 2 and 5 positions, respectively, and an ethyl group attached to the 4 position. 2-BroMo-4-ethyl-5-nitro-pyridine is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. 2-Bromo-4-ethyl-5-nitro-pyridine is a highly reactive and potentially hazardous substance that should be handled with care and in accordance with proper safety protocols.

Upstream product

• 70936-17-3 4-ethyl-5-nitropyridin-2-amine 

Downstream Products

• 929617-29-8 6-bromo-4-ethylpyridin-3-ylamine 
• 929617-30-1 5-bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine 

Relevant articles and documents

Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt

Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.