929617-31-2 Usage
Uses
Used in Medicinal Chemistry:
5-Bromo-3-chloro-1H-pyrazolo[3,4-c]pyridine serves as a valuable building block for the synthesis of various biologically active compounds. It is particularly instrumental in the development of potential drug candidates due to its ability to be incorporated into diverse chemical structures.
Used in Pharmaceutical Research:
In pharmaceutical research, 5-broMo-3-chloro-1H-pyrazolo[3,4-c]pyridine is utilized for its potential to contribute to the creation of new medications. Its unique structural attributes make it a promising intermediate in the synthesis of chemical compounds with possible pharmaceutical applications.
Used as a Reagent in Organic Synthesis:
5-Bromo-3-chloro-1H-pyrazolo[3,4-c]pyridine also operates as a reagent in organic synthesis, where it aids in the formation of complex organic compounds through chemical reactions.
Used in Chemical Research:
Furthermore, 5-broMo-3-chloro-1H-pyrazolo[3,4-c]pyridine is applied in chemical research to explore its properties and potential interactions with other molecules, which can lead to advancements in understanding and developing new chemical processes and products.
Check Digit Verification of cas no
The CAS Registry Mumber 929617-31-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,6,1 and 7 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 929617-31:
(8*9)+(7*2)+(6*9)+(5*6)+(4*1)+(3*7)+(2*3)+(1*1)=202
202 % 10 = 2
So 929617-31-2 is a valid CAS Registry Number.
929617-31-2Relevant academic research and scientific papers
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt
Zhu, Gui-Dong,Gong, Jianchun,Gandhi, Viraj B.,Woods, Keith,Luo, Yan,Liu, Xuesong,Guan, Ran,Klinghofer, Vered,Johnson, Eric F.,Stoll, Vincent S.,Mamo, Mulugeta,Li, Qun,Rosenberg, Saul H.,Giranda, Vincent L.
, p. 2441 - 2452 (2007/10/03)
Thr-211 is one of three different amino acid residues in the kinase domain of protein kinase B/Akt as compared to protein kinase A (PKA), a closely related analog in the same AGC family. In an attempt to improve the potency and selectivity of our indazole-pyridine series of Akt inhibitors over PKA, efforts have focused on the incorporation of a chemical functionality to interact with the hydroxy group of Thr-211. Several substituents including an oxygen anion, amino, and nitro groups have been introduced at the C-6 position of the indazole scaffold, leading to a significant drop in Akt potency. Incorporation of a nitrogen atom into the phenyl ring at the same position (i.e., 9f) maintained the Akt activity and, in some cases, improved the selectivity over PKA. The structure-activity relationships of the new pyridine-pyrazolopyridine series of Akt inhibitors and their structural features when bound to PKA are also discussed.
