929632-72-4

Basic information

• Product Name: Acetamide, 2,2,2-trifluoro-N-[(4-methylphenyl)sulfonyl]-N-[(1S)-1-phenylethyl]-
• CAS NO: 929632-72-4
• Molecular Formula: C17H16F3NO3S
• Molecular Weight: 371.38
• Mol File: 929632-72-4.mol

Chemical Properties

• CAS DataBase Reference: Acetamide, 2,2,2-trifluoro-N-[(4-methylphenyl)sulfonyl]-N-[(1S)-1-phenylethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, 2,2,2-trifluoro-N-[(4-methylphenyl)sulfonyl]-N-[(1S)-1-phenylethyl]-(929632-72-4)
• EPA Substance Registry System: Acetamide, 2,2,2-trifluoro-N-[(4-methylphenyl)sulfonyl]-N-[(1S)-1-phenylethyl]-(929632-72-4)

Safety Data

• Hazardous Substances Data: 929632-72-4(Hazardous Substances Data)

Upstream product

• 66558-04-1 N-[(1S)-1-phenylethan-1-yl]-4-methylbenzenesulfonamide 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 2354-91-8 (S)-2,2,2-trifluoro-(α-methylbenzyl)acetamide 
• 929632-73-5 C₁₂H₉F₆NO₂ 
• 66558-04-1 N-[(1S)-1-phenylethan-1-yl]-4-methylbenzenesulfonamide 

Relevant articles and documents

Mild deprotection of primary N-(p-toluenesulfonyl) amides with SmI 2 following trifluoroacetylation

A mild deprotection method for notoriously difficult to unmask primary N-(p-toluenesulfonyl) amides was developed during our total synthesis studies toward the marine toxin, gymnodimine. The deprotection occurs at low temperature (-78 °C) under mild conditions by initial activation of the nitrogen with a trifluoroacetyl group, followed by reductive cleavage of the p-toluenesulfonyl group with samarium diiodide. The substrate scope and functional group tolerance of this useful N-S cleavage process, which builds on related cleavage processes of other nitrogen-heteroatom bonds, is explored. Georg Thieme Verlag Stuttgart.