929634-33-3 Usage
Uses
Used in Pharmaceutical Industry:
ADAMTS-5 is used as a therapeutic target for the development of ADAMTS-5 inhibitors for the treatment of osteoporosis. These inhibitors have the potential to inhibit the degradation of aggrecan, a major component of cartilage lost in osteoporosis, thereby preserving cartilage integrity and reducing bone loss.
Additionally, ADAMTS-5 may also be used as a target for the development of drugs to treat other conditions where the inhibition of ADAMTS-5 activity could be beneficial, such as arthritis and other degenerative joint diseases. By inhibiting the activity of ADAMTS-5, it may be possible to slow down the progression of these diseases and improve the quality of life for affected individuals.
Check Digit Verification of cas no
The CAS Registry Mumber 929634-33-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,2,9,6,3 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 929634-33:
(8*9)+(7*2)+(6*9)+(5*6)+(4*3)+(3*4)+(2*3)+(1*3)=203
203 % 10 = 3
So 929634-33-3 is a valid CAS Registry Number.
929634-33-3Relevant academic research and scientific papers
5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5
Gilbert, Adam M.,Bursavich, Matthew G.,Lombardi, Sabrina,Georgiadis, Katy E.,Reifenberg, Erica,Flannery, Carl R.,Morris, Elisabeth A.
, p. 1189 - 1192 (2007/10/03)
A series of 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5 (aggrecanase-2) is described. These compounds show μM functional inhibition of ADAMTS-5, and represent a new class of agents with the potential of inhibiting degradation of aggrecan, a major component of cartilage which is lost in osteoporosis. Compound 12 is noteworthy in that it has an ADAMTS-5 IC50: 1.1 μM and shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).
