929686-69-1Relevant academic research and scientific papers
Efficient consecutive alkylation-Knoevenagel functionalisations in formyl aza-heterocycles using supported organic bases
Coelho, Alberto,El-Maatougui, Abdelaziz,Ravi?a, Enrique,Cavaleiro, José A. S.,Silva, Artur M. S.
, p. 3324 - 3328 (2006)
An efficient solution-phase parallel procedure to perform the structural diversification of some formyl aza-heterocycles employing supported organic bases (PS-BEMP, PS-TBD or Si-TBD) is described. The library synthesis is based on a consecutive alkylation-Knoevenagel functionalisation that employs alkyl halides, Michael acceptors, and malonic acid derivatives as diversity elements. Georg Thieme Verlag Stuttgart.
