Synlett p. 3324 - 3328 (2006)
Update date:2022-08-05
Topics:
Coelho, Alberto
El-Maatougui, Abdelaziz
Ravi?a, Enrique
Cavaleiro, José A. S.
Silva, Artur M. S.
An efficient solution-phase parallel procedure to perform the structural diversification of some formyl aza-heterocycles employing supported organic bases (PS-BEMP, PS-TBD or Si-TBD) is described. The library synthesis is based on a consecutive alkylation-Knoevenagel functionalisation that employs alkyl halides, Michael acceptors, and malonic acid derivatives as diversity elements. Georg Thieme Verlag Stuttgart.
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