92971-91-0

Upstream product

• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 108-95-2 phenol 
• 4362-36-1 2-(2-chloroethyl)-1,3-dioxolane 

Downstream Products

• 491-37-2 2,3-dihydro-4H-1-benzopyran-4-one 
• 1481-93-2 4-hydroxychroman 
• 22409-86-5 3-phenoxypropionaldehyde 
• 1393657-18-5 C₁₇H₁₆O₂ 
• 1393657-19-6 C₁₈H₁₈O₂ 

Relevant academic research and scientific papers

Biomimetic synthesis and anti-inflammatory evaluation of violacin A analogues

Violacin A, a chromanone derivative, isolated from a fermentation broth of Streptomyces violaceoruber, has excellent anti-inflammatory potential. Herein, a biogenetically modeled approach to synthesize violacin A and twenty-five analogues was described, which involved the preparation of aromatic polyketide precursor through Claisen condensation and its spontaneous cyclization. The inhibitory effect on nitric oxide (NO) production of all synthetic molecules was evaluated by lipopolysaccharide (LPS)-induced Raw264.7 cells. The results revealed that introduction of aliphatic amine moieties on C-7 obviously improved the anti-inflammation effect of violacin A, and also the aromatic ether instead of ketone group at side chain was favorable to increase the activity. Among them, analogue 7a and 16d were screened as the most effective anti-inflammatory candidates. Molecular mechanism research revealed that 7a and 16d acquired anti-inflammatory ability due to the inhibition of NF-κB signaling pathway.

Anti-inflammatory compound and preparation method and anti-inflammatory application thereof

The invention belongs to the field of biological medicine, relates to an anti-inflammatory compound and a preparation method and anti-inflammatory application thereof, and particularly relates to a preparation method of 2-ethyl-2, 7-dyhydroxyl-5-methyl-ch

The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction

The enantiospecific synthesis of chromanes and isochromanes obtained from an intramolecular Nicholas cyclisation reaction is discussed. During the course of this study we observed the formation of chroman-4-ones from a CAN deprotection step of a dioxolane and this is also discussed.

A Short Synthesis of 2H-1-Benzopyrans

A two-step process for synthesizing 2H-1-benzopyrans from phenols and β-halopropionaldehyde acetals is detailed.