92973-24-5

Usage

Uses

Used in Pharmaceutical Industry:
5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC is used as a chemical reagent for the preparation of novel TRPV1 antagonists. These antagonists are of interest in the development of treatments for pain management and other conditions related to the transient receptor potential vanilloid 1 (TRPV1) channel.
Used in Antibacterial Agents Development:
5-[2-(TRIFLUOROMETHYL)PHENYL]-2-FUROIC is also utilized in the preparation of potent inhibitors targeting FeII and MnII E. coli Methionine Aminopeptidase. These inhibitors have potential applications as antibacterial agents, contributing to the development of new treatments for bacterial infections and addressing the growing concern of antibiotic resistance.

InChI:InChI=1/C12H7F3O3/c13-12(14,15)8-4-2-1-3-7(8)9-5-6-10(18-9)11(16)17/h1-6H,(H,16,17)

Upstream product

• 88-14-2 2-furanoic acid 
• 88-17-5 2-(trifluoromethyl)benzenamine 
• 94098-56-3 5-(2-Trifluoromethyl-phenyl)-furan-2-carbaldehyde 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 
• 773874-52-5 5-[2-(trifluoromethyl)phenyl]furan-2-carboxylic acid methyl ester 

Downstream Products

• 92973-13-2 5-(2-Trifluoromethyl-phenyl)-furan-2-carbonyl chloride 
• 1383581-69-8 N-hydroxy-5-(2-(trifluoromethyl)phenyl)furan-2-carboxamide 
• 1365714-36-8 3,4,5-trimethoxybenzyl 5-(2-trifluoromethylphenyl)-2-furoate 
• 1202644-36-7 5-(2-trifluoromethyl-phenyl)-furan-2-carboxylic acid 3-fluoro-4-methanesulfonylamino-benzylamide 
• 1144110-85-9 C₂₂H₁₅F₃N₄OS₂ 
• 1026532-28-4 C₁₇H₉ClF₃NO₃ 
• 92972-82-2 {5-[5-(2-Trifluoromethyl-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid 
• 92973-10-9 {5-[5-(2-Trifluoromethyl-phenyl)-furan-2-yl]-tetrazol-1-yl}-acetic acid ethyl ester 
• 92973-20-1 {[5-(2-Trifluoromethyl-phenyl)-furan-2-carbonyl]-amino}-acetic acid ethyl ester 
• 92972-99-1 {[1-Chloro-1-[5-(2-trifluoromethyl-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-amino}-acetic acid ethyl ester 

Relevant academic research and scientific papers

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

Hydroxamic Acids as Potent Inhibitors of FeII and MnII E. coli Methionine Aminopeptidase: Biological Activities and X-ray Structures of Oxazole Hydroxamate-EcMetAP-Mn Complexes

New series of acids and hydroxamic acids linked to five-membered heterocycles including furan, oxazole, 1,2,4- or 1,3,4-oxadiazole, and imidazole were synthesized and tested as inhibitors against the FeII, CoII, and MnII f

Synthesis of heterocycles from arylation products of unsaturated compounds: XVIII. 5-Arylfuran-2-carboxylic acids and their application in the synthesis of 1,2,4-thiadiazole, 1,3,4-oxadiazole, and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazole derivatives

Arylation of furan-2-carboxylic acid or its methyl ester with arenediazonium chlorides in the presence of copper(II) chloride gave the corresponding 5-arylfuran-2-carboxylic acids or methyl 5-arylfuran-2- carboxylates. 5-Arylfuran-2-carbonyl chlorides rea

Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety

A series of substituted triazolothiadiazoles (6a-j and 7a-j) have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1,2,4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the presence of POCl3. The triazole (5) was obtained by the fusion of 4-methylthiophenyl acetic acid (4) with thiocarbohydrazide. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR and mass spectroscopic studies and were screened for their antimicrobial activities. The preliminary results revealed that some of the compounds exhibited promising antimicrobial activities.

Synthesis of some thiadiazolotriazinone derivatives as possible antimicrobial agents

A series of 7-substituted-3-t-butyl 4(H)-1,3,4-thiadiazolo(2,3-c)-1,2,4- triazine-4-one (3) have been synthesized by condensing 4-amino-6-t-butyl-3- mercapto-1,2,4-triazin-5(4H)-one (1) with substituted Arylfuroic acids (2) using POCl3 as a cyclizing agen

Metalloform-selective inhibition: Synthesis and structure-activity analysis of Mn(II)-form-selective inhibitors of Escherichia coli methionine aminopeptidase

Methionine aminopeptidase (MetAP) is a promising target for development of novel antibacterial, antifungal and anticancer agents. However, its physiologically relevant metal ion remains to be defined, and its inhibitors need to inhibit the in vivo metallo