92975-49-0Relevant academic research and scientific papers
Enantioselective N-Heterocyclic Carbene Catalysis via the Dienyl Acyl Azolium
Gillard, Rachel M.,Fernando, Jared E. M.,Lupton, David W.
, p. 4712 - 4716 (2018)
Herein we report the enantioselective N-heterocyclic carbene catalyzed (4+2) annulation of the dienyl acyl azolium with enolates. The reaction exploits readily accessible acyl fluorides and TMS enol ethers to give a range of highly enantio- and diastereo-enriched cyclohexenes (most >97:3 er and >20:1 dr). The reaction was found to require high nucleophilicity NHC catalysts with mechanistic studies supporting a stepwise 1,6-addition/β-lactonization.
Domino reaction of 1,3-bis(trimethylsilyloxy)-1,3-dienes with oxalyl chloride: General and stereoselective synthesis of γ-alkylidenebutenolides
Langer, Peter,Schneider, Toni,Stoll, Martin
, p. 3204 - 3214 (2007/10/03)
The Lewis acid catalyzed cyclization of oxalyl chloride with 1,3-bis-(trimethylsilyloxy)-1,3-dienes 3, derived from 1,3-dicarbonyl compounds 1, provides a new and general approach for the synthesis of γ-alkylidenebutenolides 4, a pharmacologically and syn
