92977-45-2 Usage
Uses
Used in Pharmaceutical Industry:
4-BROMO-2-CHLOROTHIAZOLE is used as a key intermediate in the synthesis of bipiperidinyl compounds, which serve as agonists of the G-protein coupled receptors GPR-119. These agonists are crucial for the development of treatments aimed at managing or preventing type 2 diabetes and related metabolic disorders. By modulating the activity of GPR-119 receptors, these bipiperidinyl compounds can enhance insulin secretion and improve glucose tolerance, offering a promising therapeutic approach for patients with type 2 diabetes.
Check Digit Verification of cas no
The CAS Registry Mumber 92977-45-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,9,7 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 92977-45:
(7*9)+(6*2)+(5*9)+(4*7)+(3*7)+(2*4)+(1*5)=182
182 % 10 = 2
So 92977-45-2 is a valid CAS Registry Number.
InChI:InChI=1/C3HBrClNS/c4-2-1-7-3(5)6-2/h1H
92977-45-2Relevant articles and documents
Polysubstituted thiazole derivatives via the halogen-dance reaction
Holzweber, Markus,Schnürch, Michael,Stanetty, Peter
, p. 3016 - 3018 (2007)
A short and efficient method for the synthesis of a series of 5-functionalized 4-bromo-2-chlorothiazole derivatives has been developed by application of the halogen-dance reaction. Georg Thieme Verlag Stuttgart.
Halogenated 2′-chlorobithiazoles via Pd-catalyzed cross-coupling reactions
Stanetty, Peter,Schnuerch, Michael,Mihovilovic, Marko D.
, p. 3754 - 3761 (2007/10/03)
Halogenated bithiazoles allow facile further functionalization and are, therefore, suitable intermediates for the synthesis of compounds with interesting biological activity or material science properties. The applicability of three coupling methods (Negi
