3034-56-8

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-2-chlorothiazole is used as a building block in the synthesis of various pharmaceutical drugs, particularly in the development of thiazole-based drugs. Its unique chemical structure allows for the creation of new drug candidates with potential therapeutic applications.
Used in Central Nervous System Applications:
5-Bromo-2-chlorothiazole has been studied for its potential effects on the central nervous system. Its ability to modulate specific pathways and receptors in the brain makes it a promising candidate for the development of drugs targeting neurological disorders and conditions.
Used in Enzyme Inhibition:
5-Bromo-2-chlorothiazole has been investigated for its ability to inhibit enzyme activity. By targeting specific enzymes involved in various biological processes, 5-BroMo-2-chlorothiazole can be used in the development of drugs that modulate enzyme function and treat related diseases.
Used in Antimicrobial Agents Development:
5-Bromo-2-chlorothiazole is known to have antimicrobial properties. Its potential use in the development of antimicrobial agents can contribute to the creation of new treatments for bacterial and fungal infections, addressing the growing issue of antibiotic resistance.

Upstream product

• 3034-22-8 5-bromo-2-aminothiazole 
• 3034-52-4 2-chlorothiazole 

Downstream Products

• 92977-45-2 4-bromo-2-chlorothiazole 
• 3034-22-8 5-bromo-2-aminothiazole 

Relevant academic research and scientific papers

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design

The N-methyl-d-aspartate receptor (NMDAR) is a Na+ and Ca2+ permeable ionotropic glutamate receptor that is activated by the coagonists glycine and glutamate. NMDARs are critical to synaptic signaling and plasticity, and their dysfunction has been implicated in a number of neurological disorders, including schizophrenia, depression, and Alzheimer's disease. Herein we describe the discovery of potent GluN2A-selective NMDAR positive allosteric modulators (PAMs) starting from a high-throughput screening hit. Using structure-based design, we sought to increase potency at the GluN2A subtype, while improving selectivity against related α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). The structure-activity relationship of channel deactivation kinetics was studied using a combination of electrophysiology and protein crystallography. Effective incorporation of these strategies resulted in the discovery of GNE-0723 (46), a highly potent and brain penetrant GluN2A-selective NMDAR PAM suitable for in vivo characterization.

THIAZOLOPYRIMIDINONES AS MODULATORS OF NMDA RECEPTOR ACTIVITY

The present invention relates to certain thiazolopyrimidinone compounds for use in modulating NMDA receptor activity, pharmaceutical compositions comprising such compounds and methods of treating neurological and psychiatric conditions.

Tetrahalogenomethanes: Simple reagents for the synthesis of monohalogenated and mixed dihalogenated aromatic heterocycles via metal-halogen exchange from lithium compounds

Tetrabromo- or tetrachloromethane and 2-lithio derivatives of aromatic heterocycles rapidly produce the corresponding 2-bromo or 2-chloro derivatives in high yields through a metal-halogen exchange mechanism. This kind of reaction was also used to obtain, in good yields, 5-bromo-2-chlorothiazole and 5-bromo-2-chloro-N-methylimidazole.