929897-10-9Relevant academic research and scientific papers
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones
Mahboobi, Siavosh,Uecker, Andrea,Cenac, Christophe,Sellmer, Andreas,Eichhorn, Emerich,Elz, Sigurd,Boehmer, Frank-D.,Dove, Stefan
, p. 2187 - 2197 (2008/02/01)
A series of bis(benzo[b]furan-2-yl)methanones was synthesized and tested for inhibition of FLT3 and PDGFR autophosphorylation. Mostly, C-5 substitution leads to PDGFR selectivity, which was strongest in the case of the 5,5′-dimethoxy derivative. The 5,5′-
