50551-56-9

Basic information

• Product Name: 5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER
• Synonyms: 5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER;5-methoxy-2-benzofurancarboxylicaciethylester;Ethyl 5-methoxy-1-benzofuran-2-carboxylate;ethyl 5-methoxybenzofuran-2-carboxylate;5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER(WXG00889)
• CAS NO: 50551-56-9
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.22
• Mol File: 50551-56-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 59 °C
• Boiling Point: 316.2°C at 760 mmHg
• Flash Point: 145°C
• Appearance: /
• Density: 1.192g/cm³
• Vapor Pressure: 0.000418mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER(50551-56-9)
• EPA Substance Registry System: 5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER(50551-56-9)

Safety Data

• Hazardous Substances Data: 50551-56-9(Hazardous Substances Data)

Usage

General Description

5-Methoxybenzofuran-2-carboxylic acid, ethyl ester is a chemical compound that belongs to the class of benzofurans. It is an ethyl ester of 5-methoxybenzofuran-2-carboxylic acid and is commonly used in organic synthesis as a building block for the production of various pharmaceuticals and agrochemicals. It has been studied for its potential therapeutic uses, including in the treatment of neurological disorders and as an anti-inflammatory agent. The compound is also used as a precursor for the preparation of other organic compounds and has been evaluated for its pharmacological properties. However, 5-Methoxybenzofuran-2-carboxylic acid, ethyl ester should be handled and used with caution, as it may pose risks to human health and the environment.

InChI:InChI=1/C12H12O4/c1-3-15-12(13)11-7-8-6-9(14-2)4-5-10(8)16-11/h4-7H,3H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 1378942-37-0 C₉H₈Br₂O₂ 
• 13939-06-5 molybdenum hexacarbonyl 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 
• 685-87-0 Diethyl 2-bromomalonate 
• 76322-07-1 2-ethoxycarbonylmethoxy-5-methoxybenzaldehyde 

Downstream Products

• 1646-28-2 5-hydroxy-benzofuran-2-carboxylic acid methyl ester 
• 23145-19-9 5-methoxy-1-benzofuran-2-carbaldehyde 
• 56172-36-2 5-Hydroxybenzofuran-2-carboxylic acid 
• 93885-41-7 (+/-)-5-Methoxydihydrocoumarilsaeure 
• 53020-42-1 5-hydroxybenzofuran-2-carbonitrile 
• 35351-22-5 methoxy-5 carboxamido-2 benzofuranne 
• 929897-14-3 [5-(benzyloxy)benzo[b]furan-2-yl][5-(benzyloxy)-1H-indol-2-yl]methanone 
• 929897-12-1 [5-(benzyloxy)benzo[b]furan-2-yl][5-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-2-yl]methanone 
• 929897-10-9 5-(benzyloxy)benzo[b]furan-2-carbonyl chloride 
• 859178-98-6 5-(benzyloxy)benzo[b]furan-2-carboxylic acid 
• 853599-45-8 5-(benzyloxy)benzo[b]furan-2-carboxylic acid ethyl ester 
• 463927-69-7 C₂₄H₁₅O₆Br₂F 
• 463927-51-7 C₂₀H₁₈O₅Br₂ 
• 463927-70-0 C₂₂H₁₁O₆Br₂F 

Relevant articles and documents

alpha-SYNUCLEIN AGGREGATE BINDING AGENT AND IMAGING METHOD

The present invention provides an α-synuclein aggregate binding agent that has high binding selectivity for an α-synuclein aggregate. The α-synuclein aggregate binding agent contains a compound represented by a formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: in the formula (I), R1 and R2 are each independently selected from the group consisting of hydrogen, alkyl, alkenyl, acyl, and hydroxyalkyl; R3 is hydrogen or halogen; the ring A is a benzene or pyridine ring; the ring B is represented by the following formula (i) or (ii): R4 and R5 are each independently selected from the group consisting of hydrogen, hydroxy, alkoxy, haloalkoxy, halohydroxyalkoxy, and aminoalkyl.

Tandem Synthesis of 2-Carboxybenzofurans via Sequential Cu-Catalyzed C-O Coupling and Mo(CO)6-Mediated Carbonylation Reactions

A modular tandem synthesis of 2-carboxybenzofurans from 2-gem-dibromovinylphenols has been established based on a sequence of Cu-catalyzed intramolecular C-O coupling and Mo(CO)6-mediated intermolecular carbonylation reactions. This protocol allowed one-step access to a broad variety of functionalized benzofuran-2-carboxylic acids, esters, and amides in good to excellent yields under Pd- and CO gas-free conditions.

Synthesis and AChE inhibitory activity of N-glycosyl benzofuran derivatives

Six N-glycosyl benzofuran derivatives were synthesized by the catalysis of organic bases and condensation agents. The benzofuran derivatives were obtained by the reaction of various salicylaldehydes in acetone, and then hydrolyzed to the corresponding carboxylic acids. Finally, the target compounds were synthesized by acylation and the reaction conditions were optimized. The acetylcholinesterase (AChE) inhibitory activity of the desired compounds was tested using Ellman's method. Most of the compounds showed acetylcholinesterase-inhibition activity; N-(2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)benzofuran-2-carbxamide (5a) showed the best acetylcholinesterase inhibition, with an inhibitory rate of 84%.