929897-94-9

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 143-33-9 sodium cyanide 

Downstream Products

• 1723-00-8 (R)-(+)-pipecolic acid 
• 19889-77-1 (+)-2R-Piperidine-2-carboxylic acid amide 
• 929897-96-1 (2R,1'R)-1-(1'-phenylethyl)piperidine-2-carboxamide 
• 929897-99-4 (2R,1'R)-1-(1'-phenylethyl)piperidine-2-carboxamide 

Relevant academic research and scientific papers

An efficient synthesis of enantiomerically pure (R)-pipecolic acid, (S)-proline, and their N-alkylated derivatives

Enantiomerically pure (R)-(+)-pipecolic acid was synthesized in four steps and 42% overall yield starting from dihydropyran and (R)-α- methylbenzylamine. A general short strategy is also described for preparing (S)-proline (47.5% overall yield) and derivatives.