19889-77-1

Basic information

• Product Name: Pipecolamide
• Synonyms: piperidinecarboxamide;Piperidine-2-carboxylic acid aMide;pipecolinamide;Pipecolamide;piperidine-2-carboxamide
• CAS NO: 19889-77-1
• Molecular Formula: C₆H₁₂N₂O
• Molecular Weight: 128.17228
• Mol File: 19889-77-1.mol
• Article Data: 22

Chemical Properties

• Melting Point: 138-140°
• Boiling Point: 311.747 °C at 760 mmHg
• Flash Point: 142.34 °C
• Appearance: /
• Density: 1.06 g/cm³
• Vapor Pressure: 0.000553mmHg at 25°C
• Refractive Index: 1.482
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: slightly sol. in Methanol
• PKA: 16.77±0.20(Predicted)
• CAS DataBase Reference: Pipecolamide(CAS DataBase Reference)
• NIST Chemistry Reference: Pipecolamide(19889-77-1)
• EPA Substance Registry System: Pipecolamide(19889-77-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 19889-77-1(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C6H12N2O/c7-6(9)5-3-1-2-4-8-5/h5,8H,1-4H2,(H2,7,9)

Upstream product

• 15862-72-3 ethyl pipecolate 
• 18650-39-0 (S)-methyl pipecolinate hydrochloride 
• 18650-38-9 (R)-piperidine-2-carboxylic acid methyl ester hydrochloride 
• 1723-00-8 (R)-(+)-pipecolic acid 
• 35677-83-9 methyl pipecolinate 
• 741633-48-7 (S)-Piperidine-2-carbonyl chloride 
• 35677-83-9 methyl (S)-pipecolinate 
• 78058-41-0 (S)-2-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 26250-84-0 (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid 
• 3105-95-1 pipecolinic acid 
• 28697-07-6 N-benzyloxycarbonyl D/L-pipecolinic acid 
• 32559-18-5 methyl piperidine-2-carboxylate hydrochloride 
• 110-89-4 piperidine 
• 4043-87-2 pipecolic Acid 

Downstream Products

• 3105-95-1 pipecolinic acid 
• 697797-45-8 benzyl-[3-tert-butoxycarbonylamino-4-(2-carbamoyl-piperidin-1-yl)-4-oxo-butyl]-carbamic acid tert-butyl ester 
• 697797-46-9 [3-tert-butoxycarbonylamino-4-(2-carbamoyl-piperidin-1-yl)-4-oxo-butyl]-(4-chloro-benzyl)-carbamic acid tert-butyl ester 
• 111478-74-1 (R)-2-(aminomethyl)piperidine 
• 1191446-35-1 (2S,αS)-α-(2-carbamoylpiperidinyl)-α-phenylacetic acid methyl ester 
• 1191446-33-9 (2S,αR)-α-(2-carbamoylpiperidinyl)-α-phenylacetic acid methyl ester 
• 1191446-36-2 (4S,9aS)-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione 
• 1191446-34-0 (4R,9aS)-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione 
• 1191446-39-5 (2R,αR)-α-(2-carbamoylpiperidinyl)-α-phenylacetic acid methyl ester 
• 1191446-37-3 (2R,αS)-α-(2-carbamoylpiperidinyl)-α-phenylacetic acid methyl ester 
• 1358163-34-4 (4S,9aS)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione 
• 1358013-53-2 (4S,9aS)-2-benzyl-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione hydrochloride 
• 1358013-69-0 (4R,9aS)-2-(2-phenylethyl)-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione 
• 1358013-57-6 (4S,9aS)-2-(2-phenylethyl)-4-phenylperhydropyrido[1,2-a]pyrazine-1,3-dione 

Relevant articles and documents

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Characterization of an enantioselective amidase from Cupriavidus sp. KNK-J915 (FERM BP-10739) useful for enzymatic resolution of racemic 3-piperidinecarboxamide

A novel amidase (CsAM) acting on (R,S)-N-benzyl-3-piperidinecarboxamide was purified from Cupriavidus sp. KNK-J915 (FERM BP-10739) and characterized. The enzyme acts on (R,S)-N-benzyl-3-piperidinecarboxamide S-selectively to yield (R)-N-benzyl-3-piperidinecarboxamide. Analytical gel filtration column chromatography and SDS-PAGE revealed that the enzyme is a tetramer with a subunit of approximately 47 kDa. It has a broad substrate spectrum against nitrogen-containing heterocyclic amides. Its optimal pH and temperature are 8.0-9.0 and 50 °C, respectively. The CsAM gene was cloned and sequenced, and it was found to comprise 1341 bp and encode a polypeptide of 46,388 Da. The deduced amino acid sequence exhibited 78% identity to that of a putative amidase (CnAM) from Cupriavidus necator JMP134. The cultured cells of recombinant Escherichia coli producing CnAM could be used for the S-selective hydrolysis of (R,S)-N-benzyl-3-piperidinecarboxamide but could not be used for the S-selective hydrolysis of (R,S)-3-piperidinecarboxamide because of its very low level of selectivity. In contrast, the cultured cells of recombinant E. coli producing CsAM could hydrolyze both (R,S)-N-benzyl-3-piperidinecarboxamide and (R,S)-3-piperidinecarboxamide with high S-selectivity.

Synthesis and anticonvulsant activity of novel 2,6-diketopiperazine derivatives. Part 2: Perhydropyrido[1,2-a]pyrazines

A new series of chiral pyrido[1,2-a]pyrazine derivatives was synthesised and evaluated in in vivo animal models of epilepsy. A significant influence of the stereochemistry of the pyrido[1,2-a]pyrazine framework on the pharmacological activity was observed