929913-27-9

Upstream product

• 128041-58-7 benzyl (1s,3s)-3-hydroxycyclobutane-1-carboxylate 
• 124-63-0 methanesulfonyl chloride 
• 480449-99-8 3-hydroxycyclobutylcarboxylic acid benzyl ester 
• 198995-91-4 benzyl 3-oxocyclobutane-1-carboxylate 
• 128041-58-7 cis-benzyl 3-hydroxycyclobutanecarboxylate 

Relevant academic research and scientific papers

PROTEASOME ACTIVITY ENHANCING COMPOUNDS

The present invention is directed towards compounds having the Formula (lb) or the Formulae (III) and pharmaceutically acceptable salts, solvates and clathrates thereof, compositions thereof, as well as towards the use of said compounds in methods for the treatment of a condition associated with a dysfunction in proteostasis.

NOVEL 4-(INDOL-3-YL)-PYRAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE

The present invention embodiments relate to compound of Formula I or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention further relates in certain embodiments to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates in certain embodiments to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also relates in certain embodiments to a process for manufacturing compounds of Formula I.

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.

OXINDOLE DERIVATIVE AS FEEDING CONTROL AGENT

Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent for diabetes and the like. (In the formula, R3 represents an optionally substituted carbamoyl group or the like; X represents a hydroxyl group or the like; W1 and W2 independently represent a single bond or methylene; R7 and R8 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; and Ar represents an optionally substituted aryl group or the like.)