930-38-1

Usage

Uses

Used in Pharmaceutical Industry:
2,5-dihydro-1-methyl-1H-phosphole 1-oxide is used as a pharmaceutical intermediate for the synthesis of various pharmaceutical compounds. Its heterocyclic structure and the presence of a phosphorus atom make it a versatile building block in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
In the field of chemical research, 2,5-dihydro-1-methyl-1H-phosphole 1-oxide serves as a valuable compound for studying the properties and reactivity of heterocyclic compounds. Its unique structure allows researchers to explore its potential in various chemical reactions and to understand the role of the phosphorus atom in its overall behavior.
Used in Material Science:
2,5-dihydro-1-methyl-1H-phosphole 1-oxide is utilized as a component in the development of advanced materials, such as catalysts, sensors, and electronic devices. Its structural features and the presence of oxygen make it a promising candidate for enhancing the performance of these materials by improving their stability, reactivity, or selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 2,5-dihydro-1-methyl-1H-phosphole 1-oxide is employed as a key intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its heterocyclic nature and the phosphorus atom contribute to the development of novel compounds with improved efficacy and selectivity in controlling pests and weeds.

InChI:InChI=1/C5H9OP/c1-7(6)4-2-3-5-7/h2-3H,4-5H2,1H3

Upstream product

• 872-37-7 1-methyl-2,5-dihydro-1H-phosphole 
• 624-83-9 methyl isocyanate 
• 111-36-4 n-butyl isocyanide 
• 39063-70-2 1-oxo-1-hydroxyphospholene, β, γ-isomer 
• 676-58-4 methylmagnesium chloride 

Downstream Products

• 36163-71-0 1-methyl-1-oxo-2,5-dihydro-1H-1λ⁵-phosphole-3-carboxylic acid 
• 36163-70-9 1-Methyl-2-phospholenoxid-2-carbonsaeure 
• 873-15-4 1-methyl-3,4-dibromophospholane 
• 61247-91-4 3r,4c-epoxy-1-methyl-phospholane 1t-oxide 
• 61183-63-9 3r,4c-epoxy-1-methyl-phospholane 1c-oxide 
• 61183-61-7 3,4-epoxy-1,1-dimethyl-phospholanium; iodide 
• 872-45-7 1-methyl-2,3-dihydro-1H-phosphole 1-oxide 
• 73312-47-7 3ξ-methyl-3ξ-oxo-(1rH,5cH)-3λ⁵-phospha-bicyclo[3.2.0]heptane-6,7-dione bis-phenylhydrazone 

Relevant academic research and scientific papers

Preparation method of phospholene oxide, substituted phospholene oxide and preparation method of substituted phospholene oxide

The invention relates to a preparation method of phospholene oxide, substituted phospholene oxide and a preparation method of the substituted phospholene oxide and belongs to the technical field of organic synthesis. The preparation method of the phospholene oxide comprises the following steps: 1) enabling phosphorus trihalide and chloroethanol to react at -10 to 40 DEG C for 0.5 to 3h so as to obtain a compound shown as a formula I; 2) enabling the compound shown as the formula I, a catalyst, a polymerization inhibitor and 1,3-butadiene to react at room temperature for 4 to 10h; then raisingthe temperature to 40 to 80 DEG C and reacting for 12 to 24h; then raising the temperature to 80 to 100 DEG C and reacting for 8 to 14h to obtain the phospholene oxide. The e preparation method of thephospholene oxide, provided by the invention, takes the phosphorus halide and the chloroethanol as raw materials, and the raw materials are easy to obtain and the price is low; reaction conditions are moderate and the method is simple and feasible and is low-cost.

1,4,2-Diazaphospholidine-3,5-diones and related compounds: A lecture on unpredictability in catalysis

1,4,2-diazaphospholidine-3,5-diones and related compounds and unpredictability in catalysis was studied. The five-membered ring species 4 6, which are all readily accessible by the McCormack reaction, optionally with subsequent hydrogenation, were selected for this study. The use of saturated species of type 4 (1-organyl-phospholanes) as catalysts led to a complete reverse in the selectivity of the reaction, in favor of the formation of the isocyanate trimers. Owing to the high activity of the corresponding P-oxides in carbodiimidization reactions, it can be assumed that the findings can be attributed to partial air oxidation of the trivalent phosphorus species applied. The symmetrical species 6, in total contrast to the other two members of the series, do not exhibit any catalytic activity with respect to isocyanates and instead react cleanly with two equivalents of isocyanate to effect the extrusion of 1,3-diene.