930-64-3Relevant academic research and scientific papers
Tandem thionation of biomass derived levulinic acid with Lawesson's reagent
Li, Zheng,Tang, Xing,Jiang, Yetao,Zuo, Miao,Wang, Yangjun,Chen, Wei,Zeng, Xianhai,Sun, Yong,Lin, Lu
, p. 2971 - 2975 (2016/06/06)
Herein we report a tandem thionation of biomass derived levulinic acid (LA) to generate thiophenic compounds. LA is initially converted to several thiophenones and then an aromatic di-thionated product, 5-methylthiophene-2-thiol, is obtained with the highest yield of 78%. An overall synthesis of thiophenic products from cellulose is also developed.
Cascade iodination-fluorination synthesis of 2-fluorothiophene and 5-fluoro-2-thienyliodonium salts
Onys'ko, Petro P.,Kim, Tetyana V.,Kiseleva, Olena I.,Rassukana, Yuliya V.,Gakh, Andrei A.
experimental part, p. 501 - 504 (2010/01/14)
The first synthesis of fluorine-containing 2-thienyliodonium salts was accomplished using cascade iodination-fluorination. According to this methodology, thiophene is first converted to bis(2-thienyl)iodonium hexafluorophosphate using an electrophilic iodination reaction. Upon heating with potassium fluoride, this salt undergoes regioselective fluorination producing 2-fluorothiophene. 2-Fluorothiophene is then iodinated again to yield fluorothienyliodonium salts.
