93002-59-6Relevant academic research and scientific papers
Design, synthesis and in vitro anticancer evaluation of 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides
Kothayer, Hend,Elshanawani, Abdalla A.,Abu Kull, Mansour E.,El-Sabbagh, Osama I.,Shekhar, Malathy P.V.,Brancale, Andrea,Jones, Arwyn T.,Westwell, Andrew D.
, p. 6886 - 6889 (2013)
Series of substituted 4,6-diamino-1,3,5-triazine-2-carbohydrazides and -carboxamides have been synthesised, based on molecular modelling of candidate structures related to the previously reported Rad6B-inhibitory diamino-triazinylmethyl benzoate anticance
Synthesis and in vitro anticancer evaluation of some 4,6-diamino-1,3,5-triazine-2-carbohydrazides as Rad6 ubiquitin conjugating enzyme inhibitors
Kothayer, Hend,Spencer, Sebastian M.,Tripathi, Kaushlendra,Westwell, Andrew D.,Palle, Komaraiah
supporting information, p. 2030 - 2034 (2016/04/05)
Series of 4-amino-6-(arylamino)-1,3,5-triazine-2-carbohydrazides (3a-e) and N′-phenyl-4,6-bis(arylamino)-1,3,5-triazine-2-carbohydrazides (6a-e), for ease of readership, we will abbreviate our compound names as 'new triazines', have been synthesized, base
Optimised synthesis of diamino-triazinylmethyl benzoates as inhibitors of Rad6B ubiquitin conjugating enzyme
Kothayer, Hend,Morelli, Matteo,Brahemi, Ghali,Elshanawani, Abdalla A.,Abu Kull, Mansour E.,El-Sabbagh, Osama I.,Shekhar, Malathy P.V.,Westwell, Andrew D.
, p. 7015 - 7018 (2015/01/09)
Recently, we have identified the first inhibitors of Rad6B, an E2 enzyme essential for post-replication DNA repair and a potential new drug target for the treatment of breast cancer. We report two newly optimised synthetic routes to our [4-amino-6-(phenylamino)-1,3,5-triazin-2-yl]methyl 4-nitrobenzoate target compounds TZ8 and TZ9 with general applicability for further structure-activity relationship studies around this pharmacophore. The key step involved the condensation/cyclisation between phenylbiguanide and either ethyl bromoacetate or dimethyloxalate in good yield.
