93017-25-5Relevant academic research and scientific papers
HETEROCYCLIC CARBOXYLATE COMPOUNDS AS GLYCOLATE OXIDASE INHIBITORS
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Page/Page column 143, (2021/05/07)
The present disclosure relates generally to modulators of human glycolate oxidase enzyme and methods of use and manufacture thereof. (I)
PRODRUG MODULATORS OF THE INTEGRATED STRESS PATHWAY
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Paragraph 00316, (2020/05/19)
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.
Posaconazole derivative, pharmaceutical composition and use thereof
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Page/Page column 264-266; 267-268, (2020/01/22)
The present disclosure provides a posaconazole derivative, a pharmaceutical composition and use thereof, which specifically include a compound represented by the following formula (I), a racemate, stereoisomer, tautomer, oxynitride, or a pharmaceutically acceptable salt thereof: The compounds of the present disclosure have strong antifungal activity, high safety, and good water solubility, without the need for the addition of a cosolvent (such as hydroxypropyl-β-cyclodextrin, sulfobutyl ether-β-cyclodextrin, and the like) with potential safety risks. Furthermore, the formulation process of the compound could have less difficulty and less cost, and therefore can be used to prepare improved antifungal drugs.
Selective phosphorylation of diols with a Lewis acid catalyst
Coppola, Kyle A.,Testa, Joseph W.,Allen, Emily E.,Sculimbrene, Bianca R.
supporting information, p. 4203 - 4206 (2015/02/02)
We report a method for the Lewis acid catalyzed phosphorylation of diols with pyrophosphates. Titanium alkoxides were found to be effective catalysts in the selective mono-phosphorylation for a range of diols. Diols of varying chain lengths and substituents were screened, to study the factors that influence mono- versus di-phosphorylation. It was discovered that 2-alkyl-2-amino-1,3-propanediols can be selectively mono-phosphorylated in up to 97% isolated yield. This structural core is mono-phosphorylated in numerous immunomodulating compounds including the FDA-approved drug, FTY720.
Selective phosphorylation of diols with a Lewis acid catalyst
Coppola, Kyle A.,Testa, Joseph W.,Allen, Emily E.,Sculimbrene, Bianca R.
supporting information, p. 4203 - 4206 (2014/07/22)
We report a method for the Lewis acid catalyzed phosphorylation of diols with pyrophosphates. Titanium alkoxides were found to be effective catalysts in the selective mono-phosphorylation for a range of diols. Diols of varying chain lengths and substituents were screened, to study the factors that influence mono- versus di-phosphorylation. It was discovered that 2-alkyl-2-amino-1,3- propanediols can be selectively mono-phosphorylated in up to 97% isolated yield. This structural core is mono-phosphorylated in numerous immunomodulating compounds including the FDA-approved drug, FTY720.
NOVEL PROSTAGLANDIN E1 DERIVATIVE, AND NANOPARTICLE HAVING SAME ENCAPSULATED THEREIN
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Page/Page column 9, (2011/09/20)
A PGE1 derivative is provided which has an excellent sustained, slow-release PGE1 action. In addition, a PGE1-derivative-containing nanoparticle produced using this PGE1 derivative is provided, which effectively targets an affected site, has excellent dru
PRODRUGS OF OXAZOLIDINONE CETP INHIBITORS
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Page/Page column 18, (2010/04/27)
The compounds of Formula I are prodrugs of CETP inhibitors having a central oxazolidinone ring. The compounds cyclize by the elimination of HX to form an oxazolidinone ring after administration to a patient.
Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Woo, Youn-Hi,Fernandes, Roberta P.M.,Proteau, Philip J.
, p. 2375 - 2385 (2007/10/03)
Analogs of the antibiotic fosmidomycin, an inhibitor of the methylerythritol phosphate pathway to isoprenoids, were synthesized and evaluated against the recombinant Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxac
