93022-03-8Relevant academic research and scientific papers
A CONVENIENT ACCESS TO 16-METHYLENE AND 16β-METHYL CORTICOSTEROIDS BY A NOVEL TRANSFORMATION OF GEMINAL BIS(PHENYLSULPHINYL) INTERMEDIATES
Boivin, Jean,Chauvet, Christine,Zard, Samir Z.
, p. 4913 - 4916 (2007/10/02)
16α-Bis(phenylsulphinyl) methyl pregnane derivative 7 gives, by a series of eliminations and rearrangements, the corresponding 16-methylene intermediate 4 on heating in the presence of triphenylphosphine.Regio- and stereoselective hydrogenation of the latter using Wilkinson's catalyst furnishes 16β-methyl corticosteroid 5.
