93026-60-9

Usage

Uses

Used in Pharmaceutical Industry:
(3-tert-butyl-phenyl)-phenyl-amine is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be incorporated into complex molecular structures, contributing to the development of new drugs with potential therapeutic applications.
Used in Fine Chemicals Industry:
In the fine chemicals industry, (3-tert-butyl-phenyl)-phenyl-amine is utilized as a key component in the production of specialty chemicals, such as fragrances, dyes, and other organic compounds, due to its unique structural properties and reactivity.
It is crucial to handle (3-tert-butyl-phenyl)-phenyl-amine with care and follow safety guidelines to minimize potential health and environmental hazards associated with this chemical compound.

Upstream product

• 5369-19-7 3-tert-butylaniline 
• 118-91-2 ortho-chlorobenzoic acid 
• 62-53-3 aniline 
• 201851-06-1 m-(tert-butyl)phenyl trifluoromethanesulfonate 
• 1393834-97-3 2-t-Bu-6-(trimethylsilyl)phenol 
• 1393834-96-2 C₁₃H₂₁BrOSi 
• 23159-87-7 2-bromo-6-(tert-butyl)phenol 
• 88-18-6 2-tert-Butylphenol 
• 1393834-98-4 2-(tert-butyl)-6-(trimethylsilyl)phenyl triflate 
• 17332-54-6 2-((3-(tert-butyl)phenyl)amino)benzoic acid 

Downstream Products

• 69386-36-3 2-(tert-butyl)-9H-carbazole 

Relevant academic research and scientific papers

Steric effects compete with aryne distortion to control regioselectivities of nucleophilic additions to 3-silylarynes

We report an experimental and computational study of 3-silylarynes. The addition of nucleophiles yield ortho-substituted products as a result of aryne distortion, but meta-substituted products form predominately when the nucleophile is large. Computations correctly predict the preferred site of attack observed in both nucleophilic addition and cycloaddition experiments. Nucleophilic additions to 3-tert-butylbenzyne, which is not significantly distorted, give meta-substituted products.

Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds

Mitotic kinesin spindle protein (KSP) is involved in the assembly of the bipolar spindle during cell division. On the basis of a common 2,3-fused indole substructure within the complex frameworks of terpendole E and other KSP inhibitors, the carbazoles with a bulky alkyl group were identified as a novel KSP inhibitory scaffold. Additionally, among several naturally occurring cell growth inhibitors with 2,3-fused indole structures,β-carboline alkaloids, harman and harmine, showed moderate inhibition of KSP.

Palladium-catalyzed direct synthesis of carbazoles via one-pot N-arylation and oxidative biaryl coupling: Synthesis and mechanistic study

(Chemical Equation Presented) An efficient catalytic system has been developed for the synthesis of carbazoles by one-pot N-arylation and oxidative biaryl coupling. A significant substituent effect of the diarylamine intermediate on oxidative coupling was observed. Mechanistic studies of oxidative coupling, including trapping of reaction intermediates and kinetic isotope effect experiments, are also presented.