930285-51-1Relevant academic research and scientific papers
Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin
Rusch, Marion,Thevenon, Arnaud,Hoepfner, Dominic,Aust, Thomas,Studer, Christian,Patoor, Maude,Rollin, Patrick,Livendahl, Madeleine,Ranieri, Beatrice,Schmitt, Esther,Spanka, Carsten,Gademann, Karl,Bouchez, Laure C.
, p. 644 - 649 (2019/02/13)
Selective and specific inhibitors of Plasmodium falciparum lysyl-tRNA synthetase represent promising therapeutic antimalarial avenues. Cladosporin was identified as a potent P. falciparum lysyl-tRNA synthetase inhibitor, with an activity against parasite
Synthesis of the core structure of cruentaren A
Vintonyak, Viktor V.,Maier, Martin E.
, p. 655 - 658 (2008/02/05)
The core structure of the macrolactone cruentaren A (1) was prepared via a ring-closing alkyne metathesis reaction. The corresponding ester 33 was constructed from the benzoic acid derivative 14 and the diol 30. As a key step in the synthesis of acid 14, an aldol reaction resulted in the required anti-OH/Me pattern. The anti-configuration in the stereotetrad of diol 30 was established by a Marshall reaction.
