930285-52-2Relevant academic research and scientific papers
Synthesis of the core structure of cruentaren A
Vintonyak, Viktor V.,Maier, Martin E.
, p. 655 - 658 (2007)
The core structure of the macrolactone cruentaren A (1) was prepared via a ring-closing alkyne metathesis reaction. The corresponding ester 33 was constructed from the benzoic acid derivative 14 and the diol 30. As a key step in the synthesis of acid 14, an aldol reaction resulted in the required anti-OH/Me pattern. The anti-configuration in the stereotetrad of diol 30 was established by a Marshall reaction.
Asymmetric total synthesis of (+)-isocryptotanshinone and formal synthesis of (?)-cryptotanshinone
Shi, Xiang,Liu, Xiaoyu,Yang, Feilong,Wang, Yong,Wang, Zhenwei,Jiao, Xiaozhen,Xie, Ping
, p. 3962 - 3967 (2019/07/03)
The first asymmetric total synthesis of (+)-isocryptotanshinone was achieved in 12 linear steps with 12% overall yield from commercially available dihydrobenzopyrone. The key step was a base-mediated cyclization reaction. In addition, the synthetic strate
Preparation method of omarigliptin intermediate
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Paragraph 0015; 0034-0036, (2018/01/09)
The invention discloses a novel synthesis method for preparing a chiral intermediate of omarigliptin. The method disclosed by the invention comprises the following steps: taking crotonyl chloride and (S)-4-benzyl-2-oxazolidone as starting raw materials and carrying out amidation, alder condensation, hydrolysis, Curtius rearrangement, Boc addition and ring opening to obtain the chiral intermediate (VI). The preparation method disclosed by the invention has the advantages of relatively short route, relatively low cost, easiness for obtaining the raw materials and relatively high yield so that the preparation method is suitable for industrial production. A formula is shown in the description.
