930296-80-3

Upstream product

• 6346-09-4 4-aminobutyrylaldehyde diethylacetal 
• 67544-77-8 (3,4-Dimethoxyphenyl)acetic acid-N-hydroxysuccinimide ester 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 

Downstream Products

• 15889-93-7 (+/-)-crispine A 
• 930296-79-0 1-{[3,4-bis(methyloxy)phenyl]acetyl}-2-(ethyloxy)pyrrolidine 
• 930296-82-5 2-(3,4-dimethoxy-phenyl)-1-(2-hydroxy-pyrrolidin-1-yl)-ethanone 

Relevant academic research and scientific papers

A facile three-step synthesis of (±)-crispine A via an acyliminium ion cyclisation

A high yielding cyclisation of the readily available N-(4,4-diethoxybutyl)-2-(3,4-dimethoxyphenyl)acetamide to 8,9-bis(methyloxy)-2,3,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-5(1H)-o ne is described. The latter can be reduced with either AlH3